Nuclear mechanics: Lamin webs and pathological blebs

Chase P. Broedersz, Clifford P. Brangwynne

Research output: Contribution to JournalArticleAcademic


Anomalies in the three-dimensional shape of the nucleus are associated with a number of genetic diseases. These shape distortions include lobulated structures, with localized bulges referred to as nuclear blebs. Blebbing can result from mutations in genes encoding lamin intermediate filaments that form the lamin cortex, a thin meshwork lining the nuclear envelope. However, the biophysical origins of nuclear blebs remain a mystery. A recent study by Funkhouser et al. provides a theoretical model in which the lamin cortex is modeled as a thin, inhomogeneous elastic shell. This model shows that partial segregation of different lamin sub-networks-each with distinct mechanical properties-can lead to shell morphologies similar to blebbed nuclei in living cells. © 2013 Landes Bioscience.
Original languageEnglish
Pages (from-to)156-159
JournalNucleus (United States)
Issue number3
Publication statusPublished - 2013
Externally publishedYes


  • Elasticity
  • Filaments
  • Lamiopathies
  • Nuclear membrane
  • Progeria
  • Shape


Dive into the research topics of 'Nuclear mechanics: Lamin webs and pathological blebs'. Together they form a unique fingerprint.

Cite this