Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

H.L. Ong; A.-M. Isvoranu; F. Schirmbeck; P. McGuire; L. Valmaggia; M.J. Kempton; M. Van Der Gaag; A. Riecher-Rössler; R.A. Bressan; N. Barrantes-Vidal; B. Nelson; G.P. Amminger; P. McGorry; C. Pantelis; M.-O. Krebs; M. Nordentoft; B. Glenthøj; S. Ruhrmann; G. Sachs; B.P.F. Rutten; J. Van Os; L. De Haan; D. Borsboom; M. Calem; S. Tognin; G. Modinos; S. Pisani; E. Hedges; E. Velthorst; T.C. Kraan; D.S. Van Dam; N. Burger; A. Politis; J. Goodall; S. Borgwardt; E. Studerus; A. Gadelha; E. Brietzke; G. Asevedo; E. Asevedo; A. Zugman; T. Domínguez-Martínez; M. Monsonet; L. Hinojosa; A. Racioppi; T.R. Kwapil; M. Kazes; C. Daban; J. Bourgin; O. Gay; C. Mam-Lam-Fook; D. Nordholm; L. Randers; K. Krakauer; L.B. Glenthøj; D. Gebhard; J. Arnhold; J. Klosterkötter; I. Lasser; B. Winklbaur; P.A. Delespaul

doi:10.1093/schbul/sbaa187

Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

H.L. Ong, A.-M. Isvoranu, F. Schirmbeck, P. McGuire, L. Valmaggia, M.J. Kempton, M. Van Der Gaag, A. Riecher-Rössler, R.A. Bressan, N. Barrantes-Vidal, B. Nelson, G.P. Amminger, P. McGorry, C. Pantelis, M.-O. Krebs, M. Nordentoft, B. Glenthøj, S. Ruhrmann, G. Sachs, B.P.F. RuttenJ. Van Os, L. De Haan, D. Borsboom, M. Calem, S. Tognin, G. Modinos, S. Pisani, E. Hedges, E. Velthorst, T.C. Kraan, D.S. Van Dam, N. Burger, A. Politis, J. Goodall, S. Borgwardt, E. Studerus, A. Gadelha, E. Brietzke, G. Asevedo, E. Asevedo, A. Zugman, T. Domínguez-Martínez, M. Monsonet, L. Hinojosa, A. Racioppi, T.R. Kwapil, M. Kazes, C. Daban, J. Bourgin, O. Gay, C. Mam-Lam-Fook, D. Nordholm, L. Randers, K. Krakauer, L.B. Glenthøj, D. Gebhard, J. Arnhold, J. Klosterkötter, I. Lasser, B. Winklbaur, P.A. Delespaul

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis.

Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms.

Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change.

Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

Original language	English
Pages (from-to)	1018-1028
Number of pages	11
Journal	Schizophrenia bulletin
Volume	47
Issue number	4
Early online date	17 Feb 2021
DOIs	https://doi.org/10.1093/schbul/sbaa187
Publication status	Published - Jul 2021

Funding

Funders	Funder number
European Commission
Not added	406.16.516
Seventh Framework Programme	241909
UK Research and Innovation	MR/J008915/1

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Ong, H. L., Isvoranu, A.-M., Schirmbeck, F., McGuire, P., Valmaggia, L., Kempton, M. J., Van Der Gaag, M., Riecher-Rössler, A., Bressan, R. A., Barrantes-Vidal, N., Nelson, B., Amminger, G. P., McGorry, P., Pantelis, C., Krebs, M.-O., Nordentoft, M., Glenthøj, B., Ruhrmann, S., Sachs, G., ... Delespaul, P. A. (2021). Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective. Schizophrenia bulletin, 47(4), 1018-1028. https://doi.org/10.1093/schbul/sbaa187

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title = "Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective",

abstract = "Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.",

author = "H.L. Ong and A.-M. Isvoranu and F. Schirmbeck and P. McGuire and L. Valmaggia and M.J. Kempton and \{Van Der Gaag\}, M. and A. Riecher-R{\"o}ssler and R.A. Bressan and N. Barrantes-Vidal and B. Nelson and G.P. Amminger and P. McGorry and C. Pantelis and M.-O. Krebs and M. Nordentoft and B. Glenth{\o}j and S. Ruhrmann and G. Sachs and B.P.F. Rutten and \{Van Os\}, J. and \{De Haan\}, L. and D. Borsboom and M. Calem and S. Tognin and G. Modinos and S. Pisani and E. Hedges and E. Velthorst and T.C. Kraan and \{Van Dam\}, D.S. and N. Burger and A. Politis and J. Goodall and S. Borgwardt and E. Studerus and A. Gadelha and E. Brietzke and G. Asevedo and E. Asevedo and A. Zugman and T. Dom{\'i}nguez-Mart{\'i}nez and M. Monsonet and L. Hinojosa and A. Racioppi and T.R. Kwapil and M. Kazes and C. Daban and J. Bourgin and O. Gay and C. Mam-Lam-Fook and D. Nordholm and L. Randers and K. Krakauer and L.B. Glenth{\o}j and D. Gebhard and J. Arnhold and J. Klosterk{\"o}tter and I. Lasser and B. Winklbaur and P.A. Delespaul",

year = "2021",

month = jul,

doi = "10.1093/schbul/sbaa187",

language = "English",

volume = "47",

pages = "1018--1028",

journal = "Schizophrenia bulletin",

issn = "0586-7614",

publisher = "Oxford University Press",

number = "4",

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Ong, HL, Isvoranu, A-M, Schirmbeck, F, McGuire, P, Valmaggia, L, Kempton, MJ, Van Der Gaag, M, Riecher-Rössler, A, Bressan, RA, Barrantes-Vidal, N, Nelson, B, Amminger, GP, McGorry, P, Pantelis, C, Krebs, M-O, Nordentoft, M, Glenthøj, B, Ruhrmann, S, Sachs, G, Rutten, BPF, Van Os, J, De Haan, L, Borsboom, D, Calem, M, Tognin, S, Modinos, G, Pisani, S, Hedges, E, Velthorst, E, Kraan, TC, Van Dam, DS, Burger, N, Politis, A, Goodall, J, Borgwardt, S, Studerus, E, Gadelha, A, Brietzke, E, Asevedo, G, Asevedo, E, Zugman, A, Domínguez-Martínez, T, Monsonet, M, Hinojosa, L, Racioppi, A, Kwapil, TR, Kazes, M, Daban, C, Bourgin, J, Gay, O, Mam-Lam-Fook, C, Nordholm, D, Randers, L, Krakauer, K, Glenthøj, LB, Gebhard, D, Arnhold, J, Klosterkötter, J, Lasser, I, Winklbaur, B & Delespaul, PA 2021, 'Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective', Schizophrenia bulletin, vol. 47, no. 4, pp. 1018-1028. https://doi.org/10.1093/schbul/sbaa187

TY - JOUR

T1 - Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis

T2 - A Network Perspective

AU - Ong, H.L.

AU - Isvoranu, A.-M.

AU - Schirmbeck, F.

AU - McGuire, P.

AU - Valmaggia, L.

AU - Kempton, M.J.

AU - Van Der Gaag, M.

AU - Riecher-Rössler, A.

AU - Bressan, R.A.

AU - Barrantes-Vidal, N.

AU - Nelson, B.

AU - Amminger, G.P.

AU - McGorry, P.

AU - Pantelis, C.

AU - Krebs, M.-O.

AU - Nordentoft, M.

AU - Glenthøj, B.

AU - Ruhrmann, S.

AU - Sachs, G.

AU - Rutten, B.P.F.

AU - Van Os, J.

AU - De Haan, L.

AU - Borsboom, D.

AU - Calem, M.

AU - Tognin, S.

AU - Modinos, G.

AU - Pisani, S.

AU - Hedges, E.

AU - Velthorst, E.

AU - Kraan, T.C.

AU - Van Dam, D.S.

AU - Burger, N.

AU - Politis, A.

AU - Goodall, J.

AU - Borgwardt, S.

AU - Studerus, E.

AU - Gadelha, A.

AU - Brietzke, E.

AU - Asevedo, G.

AU - Asevedo, E.

AU - Zugman, A.

AU - Domínguez-Martínez, T.

AU - Monsonet, M.

AU - Hinojosa, L.

AU - Racioppi, A.

AU - Kwapil, T.R.

AU - Kazes, M.

AU - Daban, C.

AU - Bourgin, J.

AU - Gay, O.

AU - Mam-Lam-Fook, C.

AU - Nordholm, D.

AU - Randers, L.

AU - Krakauer, K.

AU - Glenthøj, L.B.

AU - Gebhard, D.

AU - Arnhold, J.

AU - Klosterkötter, J.

AU - Lasser, I.

AU - Winklbaur, B.

AU - Delespaul, P.A.

PY - 2021/7

Y1 - 2021/7

N2 - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

AB - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

UR - https://www.scopus.com/pages/publications/85111024453

UR - https://www.scopus.com/inward/citedby.url?scp=85111024453&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbaa187

DO - 10.1093/schbul/sbaa187

M3 - Article

SN - 0586-7614

VL - 47

SP - 1018

EP - 1028

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

IS - 4

ER -

Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

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