OCT-Based Velocimetry for Blood Flow Quantification

Boy Braaf; Maximilian G. O. Gräfe; Néstor Uribe-Patarroyo; Brett E. Bouma; Benjamin J. Vakoc; Johannes F. de Boer; Sabine Donner; Julian Weichsel

doi:10.1007/978-3-030-16638-0_7

OCT-Based Velocimetry for Blood Flow Quantification

Boy Braaf, Maximilian G. O. Gräfe, Néstor Uribe-Patarroyo, Brett E. Bouma, Benjamin J. Vakoc, Johannes F. de Boer, Sabine Donner, Julian Weichsel

Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

Abstract

Current clinically available OCTA imaging methods are able to reliably distinguish retinal regions of significant flow from static tissue by evaluating the backscattered OCT signal from repeated measurements. By accurately controlling time delay and position offset between repeated acquisitions, quantitative OCT-based measurements of the underlying blood flow velocity and flow rate are additionally enabled. Multiple methods have been developed for this purpose that operate either on phase, amplitude, or the complex OCT signal and, accordingly, build on different physical models for interpreting the OCT signal modulation arising from moving red blood cells. Here, we present an overview of the technical background of OCT-based methods for quantitative velocimetry, describe their application for retinal imaging in vivo, and discuss their potential and limitations for future clinical ophthalmic applications.

Original language	English
Title of host publication	High Resolution Imaging in Microscopy and Ophthalmology
Subtitle of host publication	New Frontiers in Biomedical Optics
Editors	Josef F. Bille
Publisher	Springer International Publishing AG
Chapter	7
Pages	161-179
Number of pages	19
ISBN (Electronic)	9783030166380
ISBN (Print)	9783030166373
DOIs	https://doi.org/10.1007/978-3-030-16638-0_7
Publication status	Published - Aug 2019

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Braaf, B., Gräfe, M. G. O., Uribe-Patarroyo, N., Bouma, B. E., Vakoc, B. J., de Boer, J. F., Donner, S., & Weichsel, J. (2019). OCT-Based Velocimetry for Blood Flow Quantification. In J. F. Bille (Ed.), High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics (pp. 161-179). Springer International Publishing AG. https://doi.org/10.1007/978-3-030-16638-0_7

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title = "OCT-Based Velocimetry for Blood Flow Quantification",

abstract = "Current clinically available OCTA imaging methods are able to reliably distinguish retinal regions of significant flow from static tissue by evaluating the backscattered OCT signal from repeated measurements. By accurately controlling time delay and position offset between repeated acquisitions, quantitative OCT-based measurements of the underlying blood flow velocity and flow rate are additionally enabled. Multiple methods have been developed for this purpose that operate either on phase, amplitude, or the complex OCT signal and, accordingly, build on different physical models for interpreting the OCT signal modulation arising from moving red blood cells. Here, we present an overview of the technical background of OCT-based methods for quantitative velocimetry, describe their application for retinal imaging in vivo, and discuss their potential and limitations for future clinical ophthalmic applications.",

author = "Boy Braaf and Gr{\"a}fe, {Maximilian G. O.} and N{\'e}stor Uribe-Patarroyo and Bouma, {Brett E.} and Vakoc, {Benjamin J.} and {de Boer}, {Johannes F.} and Sabine Donner and Julian Weichsel",

year = "2019",

month = aug,

doi = "10.1007/978-3-030-16638-0_7",

language = "English",

isbn = "9783030166373",

pages = "161--179",

editor = "Bille, {Josef F.}",

booktitle = "High Resolution Imaging in Microscopy and Ophthalmology",

publisher = "Springer International Publishing AG",

address = "Switzerland",

}

OCT-Based Velocimetry for Blood Flow Quantification. / Braaf, Boy; Gräfe, Maximilian G. O.; Uribe-Patarroyo, Néstor et al.

High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics. ed. / Josef F. Bille. Springer International Publishing AG, 2019. p. 161-179.

Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic › peer-review

TY - CHAP

T1 - OCT-Based Velocimetry for Blood Flow Quantification

AU - Braaf, Boy

AU - Gräfe, Maximilian G. O.

AU - Uribe-Patarroyo, Néstor

AU - Bouma, Brett E.

AU - Vakoc, Benjamin J.

AU - de Boer, Johannes F.

AU - Donner, Sabine

AU - Weichsel, Julian

PY - 2019/8

Y1 - 2019/8

N2 - Current clinically available OCTA imaging methods are able to reliably distinguish retinal regions of significant flow from static tissue by evaluating the backscattered OCT signal from repeated measurements. By accurately controlling time delay and position offset between repeated acquisitions, quantitative OCT-based measurements of the underlying blood flow velocity and flow rate are additionally enabled. Multiple methods have been developed for this purpose that operate either on phase, amplitude, or the complex OCT signal and, accordingly, build on different physical models for interpreting the OCT signal modulation arising from moving red blood cells. Here, we present an overview of the technical background of OCT-based methods for quantitative velocimetry, describe their application for retinal imaging in vivo, and discuss their potential and limitations for future clinical ophthalmic applications.

AB - Current clinically available OCTA imaging methods are able to reliably distinguish retinal regions of significant flow from static tissue by evaluating the backscattered OCT signal from repeated measurements. By accurately controlling time delay and position offset between repeated acquisitions, quantitative OCT-based measurements of the underlying blood flow velocity and flow rate are additionally enabled. Multiple methods have been developed for this purpose that operate either on phase, amplitude, or the complex OCT signal and, accordingly, build on different physical models for interpreting the OCT signal modulation arising from moving red blood cells. Here, we present an overview of the technical background of OCT-based methods for quantitative velocimetry, describe their application for retinal imaging in vivo, and discuss their potential and limitations for future clinical ophthalmic applications.

UR - http://www.mendeley.com/catalogue/octbased-velocimetry-blood-flow-quantification

U2 - 10.1007/978-3-030-16638-0_7

DO - 10.1007/978-3-030-16638-0_7

M3 - Chapter

SN - 9783030166373

SP - 161

EP - 179

BT - High Resolution Imaging in Microscopy and Ophthalmology

A2 - Bille, Josef F.

PB - Springer International Publishing AG

ER -

OCT-Based Velocimetry for Blood Flow Quantification

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