Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults

Lucas Jurado-Fasoli; Xinyu Di; Isabelle Kohler; Francisco J. Osuna-Prieto; Thomas Hankemeier; Elke Krekels; Amy C. Harms; Wei Yang; Jose V. Garcia-Lario; Sonia Fernández-Veledo; Jonatan R. Ruiz; Patrick C.N. Rensen; Borja Martinez-Tellez

doi:10.1002/oby.23282

Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults

Lucas Jurado-Fasoli, Xinyu Di, Isabelle Kohler, Francisco J. Osuna-Prieto, Thomas Hankemeier, Elke Krekels, Amy C. Harms, Wei Yang, Jose V. Garcia-Lario, Sonia Fernández-Veledo, Jonatan R. Ruiz^*, Patrick C.N. Rensen, Borja Martinez-Tellez

^*Corresponding author for this work

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results: Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress–derived 8,12-iso-iPF_2α-VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion: Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.

Original language	English
Pages (from-to)	50-61
Number of pages	12
Journal	Obesity
Volume	30
Issue number	1
Early online date	12 Dec 2021
DOIs	https://doi.org/10.1002/oby.23282
Publication status	Published - Jan 2022

Bibliographical note

Funding Information:
This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA‐12264, Retos de la Sociedad (DEP2016‐79512‐R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundación Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017‐20 GENIUS‐2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012).

Funding Information:
This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigaci?n Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundaci?n Iberoamericana de Nutrici?n (FINUT), the Redes Tem?ticas de Investigaci?n Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigaci?n 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the?Junta de Andaluc?a, Consejer?a de Conocimiento, Investigaci?n y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundaci?n Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). The authors would like to thank all the participants of this study for their time and effort. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.

Publisher Copyright:
© 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

Funding

This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA‐12264, Retos de la Sociedad (DEP2016‐79512‐R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundación Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017‐20 GENIUS‐2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigaci?n Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundaci?n Iberoamericana de Nutrici?n (FINUT), the Redes Tem?ticas de Investigaci?n Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigaci?n 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the?Junta de Andaluc?a, Consejer?a de Conocimiento, Investigaci?n y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundaci?n Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). The authors would like to thank all the participants of this study for their time and effort. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.

Funders	Funder number
Dutch Federation of University Medical Centers
Koninklijke Nederlandse Akademie van Wetenschappen	CVON2017‐20 GENIUS‐2
University of Granada Plan Propio de Investigación
Fundación Alfonso Martín Escudero
AstraZeneca HealthCare Foundation
Fundación Iberoamericana de Nutrición	RD16/0022
ZonMw
Hartstichting
Ministerio de Educación, Cultura y Deporte	FPU16/02828, FPU19/01609
Ministerio de Economía y Competitividad
China Scholarship Council	201707060012
Instituto de Salud Carlos III	PI13/01393, PTA‐12264, DEP2016‐79512‐R
Universidad de Granada
European Regional Development Fund
Consejería de Conocimiento, Investigación y Universidad, Junta de Andalucía	SOMM17/6107/UGR, DOC 01151

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/oby.23282

Persistent URL (handle)

Persistent link

Cite this

@article{a9b1d494059b4293ad96022f1ae43d4f,

title = "Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults",

abstract = "Objective: Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results: Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress–derived 8,12-iso-iPF2α-VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion: Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.",

author = "Lucas Jurado-Fasoli and Xinyu Di and Isabelle Kohler and Osuna-Prieto, {Francisco J.} and Thomas Hankemeier and Elke Krekels and Harms, {Amy C.} and Wei Yang and Garcia-Lario, {Jose V.} and Sonia Fern{\'a}ndez-Veledo and Ruiz, {Jonatan R.} and Rensen, {Patrick C.N.} and Borja Martinez-Tellez",

note = "Funding Information: This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigaci{\'o}n Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA‐12264, Retos de la Sociedad (DEP2016‐79512‐R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundaci{\'o}n Iberoamericana de Nutrici{\'o}n (FINUT), the Redes Tem{\'a}ticas de Investigaci{\'o}n Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigaci{\'o}n 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andaluc{\'i}a, Consejer{\'i}a de Conocimiento, Investigaci{\'o}n y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundaci{\'o}n Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017‐20 GENIUS‐2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). Funding Information: This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigaci?n Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundaci?n Iberoamericana de Nutrici?n (FINUT), the Redes Tem?ticas de Investigaci?n Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigaci?n 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the?Junta de Andaluc?a, Consejer?a de Conocimiento, Investigaci?n y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundaci?n Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). The authors would like to thank all the participants of this study for their time and effort. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. Publisher Copyright: {\textcopyright} 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).",

year = "2022",

month = jan,

doi = "10.1002/oby.23282",

language = "English",

volume = "30",

pages = "50--61",

journal = "Obesity",

issn = "1930-7381",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults

AU - Jurado-Fasoli, Lucas

AU - Di, Xinyu

AU - Kohler, Isabelle

AU - Osuna-Prieto, Francisco J.

AU - Hankemeier, Thomas

AU - Krekels, Elke

AU - Harms, Amy C.

AU - Yang, Wei

AU - Garcia-Lario, Jose V.

AU - Fernández-Veledo, Sonia

AU - Ruiz, Jonatan R.

AU - Rensen, Patrick C.N.

AU - Martinez-Tellez, Borja

N1 - Funding Information: This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA‐12264, Retos de la Sociedad (DEP2016‐79512‐R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundación Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017‐20 GENIUS‐2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). Funding Information: This study was supported by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigaci?n Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the Fundaci?n Iberoamericana de Nutrici?n (FINUT), the Redes Tem?ticas de Investigaci?n Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigaci?n 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES), the?Junta de Andaluc?a, Consejer?a de Conocimiento, Investigaci?n y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151), the Fundaci?n Alfonso Martin Escudero, the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship Council (CSC, No. 201707060012). The authors would like to thank all the participants of this study for their time and effort. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. Publisher Copyright: © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

PY - 2022/1

Y1 - 2022/1

N2 - Objective: Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results: Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress–derived 8,12-iso-iPF2α-VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion: Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.

AB - Objective: Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid–derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods: Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results: Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress–derived 8,12-iso-iPF2α-VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion: Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.

UR - http://www.scopus.com/inward/record.url?scp=85120985366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85120985366&partnerID=8YFLogxK

U2 - 10.1002/oby.23282

DO - 10.1002/oby.23282

M3 - Article

AN - SCOPUS:85120985366

SN - 1930-7381

VL - 30

SP - 50

EP - 61

JO - Obesity

JF - Obesity

IS - 1

ER -

Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this