On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices

N.F.C. Visser; H. Lingeman; H. Irth

doi:10.1016/S0731-7085(02)00730-6

On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices

N.F.C. Visser
, H. Lingeman
, H. Irth

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

An automated and on-line solid-phase extraction (SPE)-liquid chromatography (LC) procedure is described for the determination of insulin in biological matrices. The total procedure consists of two SPEs in series, followed by RP-LC separation. During the first SPE a strong anion-exchange (SAX) cartridge (ISOLUTE, 40-90 μm, 10×4 mm i.d.) is used, followed by a RP-cartridge (Luna C

Original language	English
Pages (from-to)	295-309
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/S0731-7085(02)00730-6
Publication status	Published - 2003

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10.1016/S0731-7085(02)00730-6

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title = "On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices",

abstract = "An automated and on-line solid-phase extraction (SPE)-liquid chromatography (LC) procedure is described for the determination of insulin in biological matrices. The total procedure consists of two SPEs in series, followed by RP-LC separation. During the first SPE a strong anion-exchange (SAX) cartridge (ISOLUTE, 40-90 μm, 10×4 mm i.d.) is used, followed by a RP-cartridge (Luna C",

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doi = "10.1016/S0731-7085(02)00730-6",

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AU - Visser, N.F.C.

AU - Lingeman, H.

AU - Irth, H.

PY - 2003

Y1 - 2003

N2 - An automated and on-line solid-phase extraction (SPE)-liquid chromatography (LC) procedure is described for the determination of insulin in biological matrices. The total procedure consists of two SPEs in series, followed by RP-LC separation. During the first SPE a strong anion-exchange (SAX) cartridge (ISOLUTE, 40-90 μm, 10×4 mm i.d.) is used, followed by a RP-cartridge (Luna C

AB - An automated and on-line solid-phase extraction (SPE)-liquid chromatography (LC) procedure is described for the determination of insulin in biological matrices. The total procedure consists of two SPEs in series, followed by RP-LC separation. During the first SPE a strong anion-exchange (SAX) cartridge (ISOLUTE, 40-90 μm, 10×4 mm i.d.) is used, followed by a RP-cartridge (Luna C

U2 - 10.1016/S0731-7085(02)00730-6

DO - 10.1016/S0731-7085(02)00730-6

M3 - Article

SN - 0731-7085

VL - 32

SP - 295

EP - 309

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 2

ER -

On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices

Abstract

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