Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

G.E. de Kloe; J. Kool; R. van Elk; J.E. van Muijlwijk-Koezen; A.B. Smit; H. Lingeman; H. Irth; W.M.A. Niessen; I.J.P. de Esch

doi:10.1039/c1md00031d

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

G.E. de Kloe, J. Kool, R. van Elk, J.E. van Muijlwijk-Koezen, A.B. Smit, H. Lingeman, H. Irth, W.M.A. Niessen, I.J.P. de Esch

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

An online bioaffinity analysis system was used to screen our in-house fragment library on two related proteins, Ls- and Ac-AChBP, model proteins for nAChRs, in particular the α7 subtype. An efficient protocol for medium throughput fragment screening, hit validation and affinity ranking after single concentration injections was developed. The screening of the fragment library and the good correlation between online estimated pK

Original language	English
Pages (from-to)	590-595
Journal	MedChemComm
Volume	2
DOIs	https://doi.org/10.1039/c1md00031d
Publication status	Published - 2011

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title = "Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.",

abstract = "An online bioaffinity analysis system was used to screen our in-house fragment library on two related proteins, Ls- and Ac-AChBP, model proteins for nAChRs, in particular the α7 subtype. An efficient protocol for medium throughput fragment screening, hit validation and affinity ranking after single concentration injections was developed. The screening of the fragment library and the good correlation between online estimated pK",

author = "{de Kloe}, G.E. and J. Kool and {van Elk}, R. and {van Muijlwijk-Koezen}, J.E. and A.B. Smit and H. Lingeman and H. Irth and W.M.A. Niessen and {de Esch}, I.J.P.",

year = "2011",

doi = "10.1039/c1md00031d",

language = "English",

volume = "2",

pages = "590--595",

journal = "MedChemComm",

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AU - de Kloe, G.E.

AU - Kool, J.

AU - van Elk, R.

AU - van Muijlwijk-Koezen, J.E.

AU - Smit, A.B.

AU - Lingeman, H.

AU - Irth, H.

AU - Niessen, W.M.A.

AU - de Esch, I.J.P.

PY - 2011

Y1 - 2011

N2 - An online bioaffinity analysis system was used to screen our in-house fragment library on two related proteins, Ls- and Ac-AChBP, model proteins for nAChRs, in particular the α7 subtype. An efficient protocol for medium throughput fragment screening, hit validation and affinity ranking after single concentration injections was developed. The screening of the fragment library and the good correlation between online estimated pK

AB - An online bioaffinity analysis system was used to screen our in-house fragment library on two related proteins, Ls- and Ac-AChBP, model proteins for nAChRs, in particular the α7 subtype. An efficient protocol for medium throughput fragment screening, hit validation and affinity ranking after single concentration injections was developed. The screening of the fragment library and the good correlation between online estimated pK

U2 - 10.1039/c1md00031d

DO - 10.1039/c1md00031d

M3 - Article

SN - 2040-2503

VL - 2

SP - 590

EP - 595

JO - MedChemComm

JF - MedChemComm

ER -

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

Abstract

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