Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.

J.L. Conroy, C. Fang, J. Gu, S.O. Zeitlin, W Yang, M.A. VanAlstine, J.W. Nalwalk, P.J. Albrecht, J.E. Mazurkiewicz, A. Snyder-Keller, Z. Shan, S.Z. Zhang, M.P. Wentland, ~M. Behr, B.I. Knapp, J.M. Bidlack, O.P. Zuiderveld, R. Leurs, X. Ding, L.B> Hough

Research output: Contribution to JournalArticleAcademicpeer-review


To assess the importance of brain cytochrome P450 (P450) activity in opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine. © 2010 Nature America, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)284-286
JournalNature Neuroscience
Publication statusPublished - 2010


Dive into the research topics of 'Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.'. Together they form a unique fingerprint.

Cite this