Optical coherence tomography of the rat cochlea

B. J. F. Wong, JF de Boer, B.H. Park, ZP Chen, JS Nelson

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].
Original languageEnglish
Pages (from-to)367-370
JournalJournal of Biomedical Optics
Volume5
Issue number4
DOIs
Publication statusPublished - Oct 2000

Keywords

  • cochlea
  • ear
  • optical coherence tomography
  • low-coherence

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