Optical coherence tomography of the rat cochlea

B. J. F. Wong; JF de Boer; B.H. Park; ZP Chen; JS Nelson

doi:10.1117/1.1310165

Optical coherence tomography of the rat cochlea

B. J. F. Wong, JF de Boer, B.H. Park, ZP Chen, JS Nelson

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].

Original language	English
Pages (from-to)	367-370
Journal	Journal of Biomedical Optics
Volume	5
Issue number	4
DOIs	https://doi.org/10.1117/1.1310165
Publication status	Published - Oct 2000

Keywords

cochlea
ear
optical coherence tomography
low-coherence

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title = "Optical coherence tomography of the rat cochlea",

abstract = "Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].",

keywords = "cochlea, ear, optical coherence tomography, low-coherence",

author = "Wong, {B. J. F.} and {de Boer}, JF and B.H. Park and ZP Chen and JS Nelson",

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T1 - Optical coherence tomography of the rat cochlea

AU - Wong, B. J. F.

AU - de Boer, JF

AU - Park, B.H.

AU - Chen, ZP

AU - Nelson, JS

PY - 2000/10

Y1 - 2000/10

N2 - Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].

AB - Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].

KW - cochlea

KW - ear

KW - optical coherence tomography

KW - low-coherence

U2 - 10.1117/1.1310165

DO - 10.1117/1.1310165

M3 - Article

SN - 1083-3668

VL - 5

SP - 367

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JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 4

ER -

Optical coherence tomography of the rat cochlea

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Keywords

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