Optical tweezers for drug discovery

Matthew T.J. Halma; Jack A. Tuszynski; Gijs J.L. Wuite

doi:10.1016/j.drudis.2022.103443

Optical tweezers for drug discovery

Matthew T.J. Halma
, Jack A. Tuszynski
, Gijs J.L. Wuite^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target ‘undruggable’ proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.

Original language	English
Article number	103443
Pages (from-to)	1-12
Number of pages	12
Journal	Drug Discovery Today
Volume	28
Issue number	1
Early online date	14 Nov 2022
DOIs	https://doi.org/10.1016/j.drudis.2022.103443
Publication status	Published - Jan 2023

Bibliographical note

Funding Information:
This work is funded by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix, Grant Agreement no. 859853. We thank Dr Michael Woodside and Dr Gregory Bowman for supplying figure files.

Publisher Copyright:
© 2022 The Author(s)

Funding

This work is funded by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix, Grant Agreement no. 859853. We thank Dr Michael Woodside and Dr Gregory Bowman for supplying figure files.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biological mechanism
conformation
drug discovery
optical tweezers
target identification
undruggable proteins

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10.1016/j.drudis.2022.103443

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title = "Optical tweezers for drug discovery",

abstract = "The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target {\textquoteleft}undruggable{\textquoteright} proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.",

keywords = "biological mechanism, conformation, drug discovery, optical tweezers, target identification, undruggable proteins",

author = "Halma, \{Matthew T.J.\} and Tuszynski, \{Jack A.\} and Wuite, \{Gijs J.L.\}",

note = "Funding Information: This work is funded by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix, Grant Agreement no. 859853. We thank Dr Michael Woodside and Dr Gregory Bowman for supplying figure files. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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AU - Tuszynski, Jack A.

AU - Wuite, Gijs J.L.

N1 - Funding Information: This work is funded by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix, Grant Agreement no. 859853. We thank Dr Michael Woodside and Dr Gregory Bowman for supplying figure files. Publisher Copyright: © 2022 The Author(s)

PY - 2023/1

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N2 - The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target ‘undruggable’ proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.

AB - The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target ‘undruggable’ proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.

KW - biological mechanism

KW - conformation

KW - drug discovery

KW - optical tweezers

KW - target identification

KW - undruggable proteins

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Optical tweezers for drug discovery

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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