Abstract
This thesis focused on steps towards Therapeutic Drug Monitoring (TDM) for effective
MTX treatment and methods to measure(non)adherence towards MTX and biological
DMARDs.
We studied pharmacokinetics and –dynamics of red blood cell (RBC)-MTX-PGs, ways
to personalise MTX treatment, including a comparison of different cell types in which
MTX was measured, and a proposed PKPD model. As a bridge, drug levels of MTX
were compared with electronic monitoring of drug intake. Furthermore, adherence to
(biological) DMARDs and ways to measure and improve this were revealed.
For more information, please see the full summary.
Original language | English |
---|---|
Qualification | PhD |
Awarding Institution |
|
Supervisors/Advisors |
|
Award date | 15 Sept 2023 |
DOIs | |
Publication status | Published - 15 Sept 2023 |
Keywords
- Rheumatoid Arthritis
- Methotrexate
- Pharmacology
- Adherence to pharmacotherapy