Optimisation of MTX treatment in rheumatoid arthritis: Current reflections on a personalised approach

Renske Carolina Frieda Hebing

    Research output: PhD ThesisPhD-Thesis - Research and graduation internal

    566 Downloads (Pure)

    Abstract

    This thesis focused on steps towards Therapeutic Drug Monitoring (TDM) for effective MTX treatment and methods to measure(non)adherence towards MTX and biological DMARDs. We studied pharmacokinetics and –dynamics of red blood cell (RBC)-MTX-PGs, ways to personalise MTX treatment, including a comparison of different cell types in which MTX was measured, and a proposed PKPD model. As a bridge, drug levels of MTX were compared with electronic monitoring of drug intake. Furthermore, adherence to (biological) DMARDs and ways to measure and improve this were revealed. For more information, please see the full summary.
    Original languageEnglish
    QualificationPhD
    Awarding Institution
    • Vrije Universiteit Amsterdam
    Supervisors/Advisors
    • Nurmohamed, Mike, Supervisor, -
    • de Jonge, Robert, Supervisor, -
    • van den Bemt, Bart, Co-supervisor, -
    • Lems, W.F., Co-supervisor, -
    Award date15 Sept 2023
    DOIs
    Publication statusPublished - 15 Sept 2023

    Keywords

    • Rheumatoid Arthritis
    • Methotrexate
    • Pharmacology
    • Adherence to pharmacotherapy

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