Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

C.T. Martha, J.C. Hoogendoorn, H. Irth, W.M.A. Niessen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Current development in catalyst discovery includes combinatorial synthesis methods for the rapid generation of compound libraries combined with high-throughput performance-screening methods to determine the associated activities. Of these novel methodologies, mass spectrometry (MS) based flow chemistry methods are especially attractive due to the ability to combine sensitive detection of the formed reaction product with identification of introduced catalyst complexes. Recently, such a mass spectrometry based continuous-flow reaction detection system was utilized to screen silver-adducted ferrocenyl bidentate catalyst complexes for activity in a multicomponent synthesis of a substituted 2-imidazoline. Here, we determine the merits of different ionization approaches by studying the combination of sensitive detection of product formation in the continuous-flow system with the ability to simultaneous characterize the introduced [ferrocenyl bidentate+Ag]
Original languageEnglish
Pages (from-to)623-631
JournalTalanta
Volume84
Issue number3
DOIs
Publication statusPublished - 2011

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