Oral health-related quality of life in patients with Parkinson’s disease

Merel C. Verhoeff*, Frank Lobbezoo, Astrid M. van Leeuwen, Annemarie A. Schuller, Michail Koutris

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Background: Parkinson's disease (PD) is a neurodegenerative condition affecting the quality of life. Due to a worsening of oral health in PD patients with the progression of the disease, oral health-related quality of life (OHRQoL) could be impaired as well. Objectives: To assess whether PD patients in The Netherlands experience worse OHRQoL than historical controls, and to investigate which factors are associated with OHRQoL in PD patients. Materials & Methods: In total, 341 PD patients (65.5 ± 8.4 years) and 411 historical controls (62.6 ± 5.3 years) participated. Both groups completed a questionnaire. The PD patients were asked questions regarding demographics, PD, oral health, and OHRQoL. The historical controls filled in demographic information and questions regarding OHRQoL. The latter construct was assessed using the Dutch 14-item version of the Oral Health Impact Profile (OHIP-14). Data were analysed using independent samples t-tests and univariate and multivariate linear regression analysis. Results: The mean OHIP-14 score was higher in PD patients (19.1 ± 6.7) than in historical controls (16.5 ± 4.4) (t(239) = 6.5; p <.001). OHRQoL in PD patients was statistically significant associated with motor aspects of experiences of daily living (B = 0.31; t(315) = 7.03; p <.001), worsening of the oral environment during disease course (B = 3.39; t(315) = 4.21; p <.001), being dentate (B = −5.60; t(315) = −4.5; p <.001), tooth wear (B = 2.25; t(315) = 3.29; p =.001), and possible burning mouth syndrome (B = 5.87; t(315) = 2.87; p =.004). Conclusion: PD patients had a lower OHRQoL than historical controls. Besides, PD-related variables and oral health-related variables were associated with OHRQoL.

Original languageEnglish
Pages (from-to)398-406
Number of pages9
JournalJournal of Oral Rehabilitation
Issue number4
Early online date9 Jan 2022
Publication statusPublished - 1 Apr 2022

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.


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