Origin of Slow Stress Relaxation in the Cytoskeleton

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Dynamically cross-linked semiflexible biopolymers such as the actin cytoskeleton govern the mechanical behavior of living cells. Semiflexible biopolymers nonlinearly stiffen in response to mechanical loads, whereas the cross-linker dynamics allow for stress relaxation over time. Here we show, through rheology and theoretical modeling, that the combined nonlinearity in time and stress leads to an unexpectedly slow stress relaxation, similar to the dynamics of disordered systems close to the glass transition. Our work suggests that transient cross-linking combined with internal stress can explain prior reports of soft glassy rheology of cells, in which the shear modulus increases weakly with frequency.

Original languageEnglish
Article number218102
JournalPhysical Review Letters
Volume122
Issue number21
DOIs
Publication statusPublished - 29 May 2019

Fingerprint

biopolymers
stress relaxation
rheology
residual stress
nonlinearity
shear
glass
cells

Cite this

@article{6d10c8986f9144a3937e54a4da6e49a9,
title = "Origin of Slow Stress Relaxation in the Cytoskeleton",
abstract = "Dynamically cross-linked semiflexible biopolymers such as the actin cytoskeleton govern the mechanical behavior of living cells. Semiflexible biopolymers nonlinearly stiffen in response to mechanical loads, whereas the cross-linker dynamics allow for stress relaxation over time. Here we show, through rheology and theoretical modeling, that the combined nonlinearity in time and stress leads to an unexpectedly slow stress relaxation, similar to the dynamics of disordered systems close to the glass transition. Our work suggests that transient cross-linking combined with internal stress can explain prior reports of soft glassy rheology of cells, in which the shear modulus increases weakly with frequency.",
author = "Yuval Mulla and Mackintosh, {F. C.} and Koenderink, {Gijsje H.}",
year = "2019",
month = "5",
day = "29",
doi = "10.1103/PhysRevLett.122.218102",
language = "English",
volume = "122",
journal = "Physical Review Letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "21",

}

Origin of Slow Stress Relaxation in the Cytoskeleton. / Mulla, Yuval; Mackintosh, F. C.; Koenderink, Gijsje H.

In: Physical Review Letters, Vol. 122, No. 21, 218102, 29.05.2019.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Origin of Slow Stress Relaxation in the Cytoskeleton

AU - Mulla, Yuval

AU - Mackintosh, F. C.

AU - Koenderink, Gijsje H.

PY - 2019/5/29

Y1 - 2019/5/29

N2 - Dynamically cross-linked semiflexible biopolymers such as the actin cytoskeleton govern the mechanical behavior of living cells. Semiflexible biopolymers nonlinearly stiffen in response to mechanical loads, whereas the cross-linker dynamics allow for stress relaxation over time. Here we show, through rheology and theoretical modeling, that the combined nonlinearity in time and stress leads to an unexpectedly slow stress relaxation, similar to the dynamics of disordered systems close to the glass transition. Our work suggests that transient cross-linking combined with internal stress can explain prior reports of soft glassy rheology of cells, in which the shear modulus increases weakly with frequency.

AB - Dynamically cross-linked semiflexible biopolymers such as the actin cytoskeleton govern the mechanical behavior of living cells. Semiflexible biopolymers nonlinearly stiffen in response to mechanical loads, whereas the cross-linker dynamics allow for stress relaxation over time. Here we show, through rheology and theoretical modeling, that the combined nonlinearity in time and stress leads to an unexpectedly slow stress relaxation, similar to the dynamics of disordered systems close to the glass transition. Our work suggests that transient cross-linking combined with internal stress can explain prior reports of soft glassy rheology of cells, in which the shear modulus increases weakly with frequency.

UR - http://www.scopus.com/inward/record.url?scp=85066429073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066429073&partnerID=8YFLogxK

U2 - 10.1103/PhysRevLett.122.218102

DO - 10.1103/PhysRevLett.122.218102

M3 - Article

VL - 122

JO - Physical Review Letters

JF - Physical Review Letters

SN - 0031-9007

IS - 21

M1 - 218102

ER -