Origin of the "Endo Rule" in Diels-Alder reactions

I. Fernandez, F.M. Bickelhaupt

Research output: Contribution to JournalArticleAcademicpeer-review


Detailed density functional theory calculations definitively rationalize the preference for the endo cycloadduct (also known as endo rule) in text-book thermal Diels-Alder reactions involving maleic anhydride and cyclopentadiene or butadiene. This selectivity is mainly caused by an unfavorable steric arrangement in the transition-state region of the exo pathway which translates into a more destabilizing activation strain. In contrast with the widely accepted, orbital-interaction-based explanation for the endo rule, it is found that neither the orbital interactions nor the total interaction between the deformed reactants contributes to the endo selectivity. © 2013 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)371-376
JournalJournal of Computational Chemistry
Issue number35
Publication statusPublished - 2014


Dive into the research topics of 'Origin of the "Endo Rule" in Diels-Alder reactions'. Together they form a unique fingerprint.

Cite this