Abstract
BACKGROUND: Orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, but existing evidence is contradictory.
METHODS: MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947) were systematically searched for studies on the association of OH and physical functioning in older adults, categorized as: balance, gait characteristics, walking speed, Timed Up and Go time, handgrip strength (HGS), physical frailty, exercise tolerance, physical activity, activities of daily living (ADL), and performance on the Hoehn and Yahr scale (HY) and Unified Parkinson's Disease Rating Scale (UPDRS). Study quality was assessed using the Newcastle Ottawa Scale.
RESULTS: Forty-two studies were included in the systematic review (29,421 individuals) and 29 studies in the meta-analyses (23,879 individuals). Sixteen out of 42 studies reported a significant association of OH with worse physical functioning. Meta-analysis showed a significant association of OH with impaired balance, ADL performance and HY/UPDRS III performance, but not with gait characteristics, mobility, walking speed, TUG, HGS, physical frailty, exercise tolerance, physical activity and UPDRS II performance.
CONCLUSIONS: OH was associated with impaired balance, ADL performance and HY/UPDRS III performance, but not with other physical functioning categories. The results suggest that OH interventions could potentially improve some aspects of physical functioning.
Original language | English |
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Pages (from-to) | 122-144 |
Number of pages | 23 |
Journal | Ageing Research Reviews |
Volume | 48 |
Early online date | 28 Oct 2018 |
DOIs | |
Publication status | Published - Dec 2018 |
Funding
This work was supported by the Dutch Technology Foundation TTW [NeuroCIMT perspective grant 2015]; and the European Union’s Horizon 2020 research and innovation program [No 689238 , 2015; No 675003 , 2015]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funders | Funder number |
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Horizon 2020 Framework Programme | 689238, 675003 |
Keywords
- ADL
- Balance
- Gait
- Handgrip strength
- Timed up and go
- Walking speed