Osseointegration and anti-infection of dental implant under osteoporotic conditions promoted by gallium oxide nano-layer coated titanium dioxide nanotube arrays

Litao Yao, Abdullrahman M. Al-Bishari, Jiating Shen, Zhen Wang, Tingting Liu, Lieping Sheng, Gang Wu, Lei Lu*, Lihua Xu*, Jinsong Liu

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The insufficient osteointegration between titanium (Ti) based dental implants and surrounding bone tissue under osteoporotic conditions, as well as implant-associated infections usually associate with dental implant failure. Gallium (Ga) has drawn increasing attention due to its antibacterial ability and pro-osteogenic property. Herein, we established a facile strategy to deposit gallium oxide (Ga2O3) nano-layer on titanium dioxide nanotube (TNT) arrays by magnetron sputtering. Both Ga2O3@TNT/50 W and Ga2O3@TNT/100 W specimens were prepared at different powers (50 W and 100 W), respectively, which all achieved a sustained release of Ga3+ ion for over 14 days. In vitro results showed that Ga2O3@TNT/50 W sample has good biocompatibility and osteogenic activity, compared with TNT and Ga2O3@TNT/100 W samples. Moreover, both Ga2O3@TNT/50 W and Ga2O3@TNT/100 W samples possess potent antibacterial properties, due to the released Ga3+ ion. Furthermore, in vivo results indicated that the Ga2O3@TNT/50 W showed excellent in vivo antibacterial ability and promoted new bone formation effectively compared with TNT implants in an osteoporotic rat model with Staphylococcus aureus (S. aureus) infection. Therefore, such Ga2O3 deposition coating strategy provides a valuable guidance for the potential future development of Ga-doped dental implants and TNT based drug loading surfaces for clinical applications.

Original languageEnglish
Pages (from-to)22961-22969
Number of pages9
JournalCeramics International
Volume49
Issue number14, Part A
Early online date14 Apr 2023
DOIs
Publication statusPublished - 15 Jul 2023

Bibliographical note

Funding Information:
This work is supported by the National Natural Science Foundation of China ( 81870810 and 82071170 ), Zhejiang Provincial Science and Technology Project for Public Welfare ( LGF21H140004 , LTGY23H140001 ), Wenzhou Public Welfare Science and Technology Project ( ZY2019009 and 2021Y0441 ) and Traditional Chinese Medicine Science and Technology Program of Zhejiang Province ( 2023ZR109 ).

Publisher Copyright:
© 2023

Keywords

  • Antibacterial
  • Gallium oxide
  • Magnetron sputtering
  • Nanotube
  • Osteointegration
  • Titanium

Fingerprint

Dive into the research topics of 'Osseointegration and anti-infection of dental implant under osteoporotic conditions promoted by gallium oxide nano-layer coated titanium dioxide nanotube arrays'. Together they form a unique fingerprint.

Cite this