Osteoporotic fractures may impair life as much as the complications of diabetes

Zoltán Vokó; Katalin Gáspár; András Inotai; Csaba Horváth; Katalin Bors; Gábor Speer; Zoltán Kaló

doi:10.1111/jep.12800

Osteoporotic fractures may impair life as much as the complications of diabetes

Zoltán Vokó, Katalin Gáspár, András Inotai, Csaba Horváth, Katalin Bors, Gábor Speer, Zoltán Kaló

Health Economics and Health Technology Assessment

Research output: Contribution to Journal › Article › Academic › peer-review

20 Downloads (Pure)

Abstract

RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL).

METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender.

RESULTS: The effects of certain of osteoporotic fractures and diabetes complications were similar in size measured by the EQ-5D. Patients with hip fractures and compressions of the vertebrae suffered more than 0.2 drop in their QoL, which is comparable in size to the most severe complications of diabetes, such as vision loss and amputations.

CONCLUSIONS: The use of mortality and premature mortality as the traditional measures of disease burden in public health policy making means that diseases which strongly affect QoL but less survival might not get the necessary priority. This is especially the case in low-income and middle-income countries where studies on QoL are scarce. Our comparative analysis, which showed that osteoporotic fractures reduce QoL as much as major complications of diabetes, highlights the need for comprehensive disease burden assessment, including losses in functionality and QoL, to support decision making.

Original language	English
Pages (from-to)	1375-1380
Number of pages	6
Journal	Journal of Evaluation in Clinical Practice
Volume	23
Issue number	6
Early online date	12 Sept 2017
DOIs	https://doi.org/10.1111/jep.12800
Publication status	Published - Dec 2017

Bibliographical note

Funding

The study was financed by Novartis Hungary Ltd. and Sandoz Hungary Ltd. Syreon Research Institute was a contractual partner of Novartis Hungary Ltd. in the project. ZV, KG, AI, and KZ were employees of Syreon Research Institute, and GS was employee of Novartis Hungary Ltd. at the time the study was performed. CsH and KB declare that they have no conflict of interest.

Funders	Funder number
Novartis Hungary Ltd.
Sandoz Hungary Ltd.

Keywords

Age Factors
Aged
Aged, 80 and over
Cross-Sectional Studies
Diabetes Complications/epidemiology
Female
Humans
Hungary
Male
Middle Aged
Osteoporotic Fractures/epidemiology
Quality of Life
Severity of Illness Index
Sex Factors
Socioeconomic Factors
Survival Analysis

Access to Document

10.1111/jep.12800

Vok - Osteoporotic fractures may impair life as much as the complications of diabetesFinal published version, 372 KBLicence: Article 25fa Dutch Copyright Act

Persistent URL (handle)

Persistent link

Cite this

@article{6f45befaa97a4965a7de91bb71cac7c2,

title = "Osteoporotic fractures may impair life as much as the complications of diabetes",

abstract = "RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL).METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender.RESULTS: The effects of certain of osteoporotic fractures and diabetes complications were similar in size measured by the EQ-5D. Patients with hip fractures and compressions of the vertebrae suffered more than 0.2 drop in their QoL, which is comparable in size to the most severe complications of diabetes, such as vision loss and amputations.CONCLUSIONS: The use of mortality and premature mortality as the traditional measures of disease burden in public health policy making means that diseases which strongly affect QoL but less survival might not get the necessary priority. This is especially the case in low-income and middle-income countries where studies on QoL are scarce. Our comparative analysis, which showed that osteoporotic fractures reduce QoL as much as major complications of diabetes, highlights the need for comprehensive disease burden assessment, including losses in functionality and QoL, to support decision making.",

keywords = "Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Diabetes Complications/epidemiology, Female, Humans, Hungary, Male, Middle Aged, Osteoporotic Fractures/epidemiology, Quality of Life, Severity of Illness Index, Sex Factors, Socioeconomic Factors, Survival Analysis",

author = "Zolt{\'a}n Vok{\'o} and Katalin G{\'a}sp{\'a}r and Andr{\'a}s Inotai and Csaba Horv{\'a}th and Katalin Bors and G{\'a}bor Speer and Zolt{\'a}n Kal{\'o}",

note = "{\textcopyright} 2017 John Wiley & Sons, Ltd.",

year = "2017",

month = dec,

doi = "10.1111/jep.12800",

language = "English",

volume = "23",

pages = "1375--1380",

journal = "Journal of Evaluation in Clinical Practice",

issn = "1356-1294",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - Osteoporotic fractures may impair life as much as the complications of diabetes

AU - Vokó, Zoltán

AU - Gáspár, Katalin

AU - Inotai, András

AU - Horváth, Csaba

AU - Bors, Katalin

AU - Speer, Gábor

AU - Kaló, Zoltán

PY - 2017/12

Y1 - 2017/12

N2 - RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL).METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender.RESULTS: The effects of certain of osteoporotic fractures and diabetes complications were similar in size measured by the EQ-5D. Patients with hip fractures and compressions of the vertebrae suffered more than 0.2 drop in their QoL, which is comparable in size to the most severe complications of diabetes, such as vision loss and amputations.CONCLUSIONS: The use of mortality and premature mortality as the traditional measures of disease burden in public health policy making means that diseases which strongly affect QoL but less survival might not get the necessary priority. This is especially the case in low-income and middle-income countries where studies on QoL are scarce. Our comparative analysis, which showed that osteoporotic fractures reduce QoL as much as major complications of diabetes, highlights the need for comprehensive disease burden assessment, including losses in functionality and QoL, to support decision making.

AB - RATIONALE, AIMS, AND OBJECTIVES: To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL).METHOD: A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macrovascular complications of diabetes on QoL using the EQ-5D questionnaire. Ordinary least-squares regression was performed for the analysis to control for age and gender.RESULTS: The effects of certain of osteoporotic fractures and diabetes complications were similar in size measured by the EQ-5D. Patients with hip fractures and compressions of the vertebrae suffered more than 0.2 drop in their QoL, which is comparable in size to the most severe complications of diabetes, such as vision loss and amputations.CONCLUSIONS: The use of mortality and premature mortality as the traditional measures of disease burden in public health policy making means that diseases which strongly affect QoL but less survival might not get the necessary priority. This is especially the case in low-income and middle-income countries where studies on QoL are scarce. Our comparative analysis, which showed that osteoporotic fractures reduce QoL as much as major complications of diabetes, highlights the need for comprehensive disease burden assessment, including losses in functionality and QoL, to support decision making.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Cross-Sectional Studies

KW - Diabetes Complications/epidemiology

KW - Female

KW - Humans

KW - Hungary

KW - Male

KW - Middle Aged

KW - Osteoporotic Fractures/epidemiology

KW - Quality of Life

KW - Severity of Illness Index

KW - Sex Factors

KW - Socioeconomic Factors

KW - Survival Analysis

UR - http://www.scopus.com/inward/record.url?scp=85038847872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038847872&partnerID=8YFLogxK

U2 - 10.1111/jep.12800

DO - 10.1111/jep.12800

M3 - Article

C2 - 28895276

SN - 1356-1294

VL - 23

SP - 1375

EP - 1380

JO - Journal of Evaluation in Clinical Practice

JF - Journal of Evaluation in Clinical Practice

IS - 6

ER -

Osteoporotic fractures may impair life as much as the complications of diabetes

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this