Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map

Isabel Galicia Ernst; Gabriel Torbahn; Lukas Schwingshackl; Helge Knüttel; Robert Kob; Wolfgang Kemmler; Cornel C. Sieber; John A. Batsis; Dennis T. Villareal; Nanette Stroebele-Benschop; Marjolein Visser; Dorothee Volkert; Eva Kiesswetter; Daniel Schoene

doi:10.1111/obr.13497

Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map

Isabel Galicia Ernst^*, Gabriel Torbahn, Lukas Schwingshackl, Helge Knüttel, Robert Kob, Wolfgang Kemmler, Cornel C. Sieber, John A. Batsis, Dennis T. Villareal, Nanette Stroebele-Benschop, Marjolein Visser, Dorothee Volkert, Eva Kiesswetter, Daniel Schoene

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Obesity and sarcopenic obesity (SO) are characterized by excess body fat with or without low muscle mass affecting bio-psycho-social health, functioning, and subsequently quality of life in older adults. We mapped outcomes addressed in randomized controlled trials (RCTs) on lifestyle interventions in community-dwelling older people with (sarcopenic) obesity. Systematic searches in Medline, Embase, Cochrane Central, CINAHL, PsycInfo, Web of Science were conducted. Two reviewers independently performed screening and extracted data on outcomes, outcome domains, assessment methods, units, and measurement time. A bubble chart and heat maps were generated to visually display results. Fifty-four RCTs (7 in SO) reporting 464 outcomes in the outcome domains: physical function (n = 42), body composition/anthropometry (n = 120), biomarkers (n = 190), physiological (n = 30), psychological (n = 47), quality of life (n = 14), pain (n = 4), sleep (n = 2), medications (n = 3), and risk of adverse health events (n = 5) were included. Heterogeneity in terms of outcome definition, assessment methods, measurement units, and measurement times was found. Psychological and quality of life domains were investigated in a minority of studies. There is almost no information beyond 52 weeks. This evidence map is the first step of a harmonization process to improve comparability of RCTs in older people with (sarcopenic) obesity and facilitate the derivation of evidence-based clinical decisions.

Original language	English
Article number	e13497
Pages (from-to)	1-16
Number of pages	16
Journal	Obesity reviews
Volume	23
Issue number	10
Early online date	26 Jul 2022
DOIs	https://doi.org/10.1111/obr.13497
Publication status	Published - Oct 2022

Bibliographical note

Funding Information:
This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02‐04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf . We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL.

Funding Information:
IGE, GT, LS, HK, RK, WK, NSB, MV, DVo, EK, DS, and CCS have no conflict of interest to declare. JB has no conflicts of interest related to the submitted manuscript. Outside the submitted work, JB has received support: NIH‐K23‐AG‐051681; grants: K23‐AG‐051681, R01‐AG‐067416, R41‐AG‐071290, R01‐AG‐058615, U01‐AG‐071450, and 1UG1HD107692; payment or honoraria for lectures or presentations: Obesity Medicine Association, Wake Forest Baptist Health, Hong Kong Research Grants Council, NIH Reviewer Payment, and Teaching Kitchen Collaborative. Patents planned, issued, or pending: No. 62/672,827. Participation on a Data Safety Monitoring Board or Advisory Board: Nutrition for precision health and other financial or non‐financial interest: Equity in SynchroHealth LLC, remote monitoring company.

Funding Information:
This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02-04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf. We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL.

Publisher Copyright:
© 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

Funding

This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02‐04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf . We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL. IGE, GT, LS, HK, RK, WK, NSB, MV, DVo, EK, DS, and CCS have no conflict of interest to declare. JB has no conflicts of interest related to the submitted manuscript. Outside the submitted work, JB has received support: NIH‐K23‐AG‐051681; grants: K23‐AG‐051681, R01‐AG‐067416, R41‐AG‐071290, R01‐AG‐058615, U01‐AG‐071450, and 1UG1HD107692; payment or honoraria for lectures or presentations: Obesity Medicine Association, Wake Forest Baptist Health, Hong Kong Research Grants Council, NIH Reviewer Payment, and Teaching Kitchen Collaborative. Patents planned, issued, or pending: No. 62/672,827. Participation on a Data Safety Monitoring Board or Advisory Board: Nutrition for precision health and other financial or non‐financial interest: Equity in SynchroHealth LLC, remote monitoring company. This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02-04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf. We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL.

Keywords

aged
evidence map
lifestyle interventions
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/obr.13497

Persistent URL (handle)

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Cite this

Galicia Ernst, I., Torbahn, G., Schwingshackl, L., Knüttel, H., Kob, R., Kemmler, W., Sieber, C. C., Batsis, J. A., Villareal, D. T., Stroebele-Benschop, N., Visser, M., Volkert, D., Kiesswetter, E., & Schoene, D. (2022). Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map. Obesity reviews, 23(10), 1-16. Article e13497. https://doi.org/10.1111/obr.13497

@article{3c1089eb25ae461cb47e1b2043331387,

title = "Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map",

abstract = "Obesity and sarcopenic obesity (SO) are characterized by excess body fat with or without low muscle mass affecting bio-psycho-social health, functioning, and subsequently quality of life in older adults. We mapped outcomes addressed in randomized controlled trials (RCTs) on lifestyle interventions in community-dwelling older people with (sarcopenic) obesity. Systematic searches in Medline, Embase, Cochrane Central, CINAHL, PsycInfo, Web of Science were conducted. Two reviewers independently performed screening and extracted data on outcomes, outcome domains, assessment methods, units, and measurement time. A bubble chart and heat maps were generated to visually display results. Fifty-four RCTs (7 in SO) reporting 464 outcomes in the outcome domains: physical function (n = 42), body composition/anthropometry (n = 120), biomarkers (n = 190), physiological (n = 30), psychological (n = 47), quality of life (n = 14), pain (n = 4), sleep (n = 2), medications (n = 3), and risk of adverse health events (n = 5) were included. Heterogeneity in terms of outcome definition, assessment methods, measurement units, and measurement times was found. Psychological and quality of life domains were investigated in a minority of studies. There is almost no information beyond 52 weeks. This evidence map is the first step of a harmonization process to improve comparability of RCTs in older people with (sarcopenic) obesity and facilitate the derivation of evidence-based clinical decisions.",

keywords = "aged, evidence map, lifestyle interventions, obesity",

author = "{Galicia Ernst}, Isabel and Gabriel Torbahn and Lukas Schwingshackl and Helge Kn{\"u}ttel and Robert Kob and Wolfgang Kemmler and Sieber, {Cornel C.} and Batsis, {John A.} and Villareal, {Dennis T.} and Nanette Stroebele-Benschop and Marjolein Visser and Dorothee Volkert and Eva Kiesswetter and Daniel Schoene",

note = "Funding Information: This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02‐04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf . We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL. Funding Information: IGE, GT, LS, HK, RK, WK, NSB, MV, DVo, EK, DS, and CCS have no conflict of interest to declare. JB has no conflicts of interest related to the submitted manuscript. Outside the submitted work, JB has received support: NIH‐K23‐AG‐051681; grants: K23‐AG‐051681, R01‐AG‐067416, R41‐AG‐071290, R01‐AG‐058615, U01‐AG‐071450, and 1UG1HD107692; payment or honoraria for lectures or presentations: Obesity Medicine Association, Wake Forest Baptist Health, Hong Kong Research Grants Council, NIH Reviewer Payment, and Teaching Kitchen Collaborative. Patents planned, issued, or pending: No. 62/672,827. Participation on a Data Safety Monitoring Board or Advisory Board: Nutrition for precision health and other financial or non‐financial interest: Equity in SynchroHealth LLC, remote monitoring company. Funding Information: This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02-04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf. We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.",

year = "2022",

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language = "English",

volume = "23",

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Galicia Ernst, I, Torbahn, G, Schwingshackl, L, Knüttel, H, Kob, R, Kemmler, W, Sieber, CC, Batsis, JA, Villareal, DT, Stroebele-Benschop, N, Visser, M, Volkert, D, Kiesswetter, E & Schoene, D 2022, 'Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map', Obesity reviews, vol. 23, no. 10, e13497, pp. 1-16. https://doi.org/10.1111/obr.13497

Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map. / Galicia Ernst, Isabel; Torbahn, Gabriel; Schwingshackl, Lukas et al.
In: Obesity reviews, Vol. 23, No. 10, e13497, 10.2022, p. 1-16.

Research output: Contribution to Journal › Review article › Academic › peer-review

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AU - Kemmler, Wolfgang

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AU - Villareal, Dennis T.

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AU - Visser, Marjolein

AU - Volkert, Dorothee

AU - Kiesswetter, Eva

AU - Schoene, Daniel

N1 - Funding Information: This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02‐04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf . We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL. Funding Information: IGE, GT, LS, HK, RK, WK, NSB, MV, DVo, EK, DS, and CCS have no conflict of interest to declare. JB has no conflicts of interest related to the submitted manuscript. Outside the submitted work, JB has received support: NIH‐K23‐AG‐051681; grants: K23‐AG‐051681, R01‐AG‐067416, R41‐AG‐071290, R01‐AG‐058615, U01‐AG‐071450, and 1UG1HD107692; payment or honoraria for lectures or presentations: Obesity Medicine Association, Wake Forest Baptist Health, Hong Kong Research Grants Council, NIH Reviewer Payment, and Teaching Kitchen Collaborative. Patents planned, issued, or pending: No. 62/672,827. Participation on a Data Safety Monitoring Board or Advisory Board: Nutrition for precision health and other financial or non‐financial interest: Equity in SynchroHealth LLC, remote monitoring company. Funding Information: This work was funded by the German Federal Ministry of Education and Research (BMBF) grant number (01KG1903). Some preliminary results of this evidence map have been presented in German at the online congress of the German Geriatrics Society (02-04.09.2021) https://doi.org/10.1007/s00391-021-01948-x.pdf. We thank Edith Motschall for peer reviewing the search strategy. The present work was performed in partial fulfillment of the requirements for obtaining the degree Dr. rer. Biol. Hum (Doctoral Degree in Human Biology) for Isabel Galicia Ernst. Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

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N2 - Obesity and sarcopenic obesity (SO) are characterized by excess body fat with or without low muscle mass affecting bio-psycho-social health, functioning, and subsequently quality of life in older adults. We mapped outcomes addressed in randomized controlled trials (RCTs) on lifestyle interventions in community-dwelling older people with (sarcopenic) obesity. Systematic searches in Medline, Embase, Cochrane Central, CINAHL, PsycInfo, Web of Science were conducted. Two reviewers independently performed screening and extracted data on outcomes, outcome domains, assessment methods, units, and measurement time. A bubble chart and heat maps were generated to visually display results. Fifty-four RCTs (7 in SO) reporting 464 outcomes in the outcome domains: physical function (n = 42), body composition/anthropometry (n = 120), biomarkers (n = 190), physiological (n = 30), psychological (n = 47), quality of life (n = 14), pain (n = 4), sleep (n = 2), medications (n = 3), and risk of adverse health events (n = 5) were included. Heterogeneity in terms of outcome definition, assessment methods, measurement units, and measurement times was found. Psychological and quality of life domains were investigated in a minority of studies. There is almost no information beyond 52 weeks. This evidence map is the first step of a harmonization process to improve comparability of RCTs in older people with (sarcopenic) obesity and facilitate the derivation of evidence-based clinical decisions.

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Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity—An evidence map

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

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Cite this