Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age

Salome Scholtens; Alet H Wijga; Jacob C Seidell; Bert Brunekreef; Johan C de Jongste; Ulrike Gehring; Dirkje S Postma; Marjan Kerkhof; Henriette A Smit

doi:10.1016/j.jaci.2009.02.029

Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age

Salome Scholtens, Alet H Wijga, Jacob C Seidell, Bert Brunekreef, Johan C de Jongste, Ulrike Gehring, Dirkje S Postma, Marjan Kerkhof, Henriette A Smit

Health Sciences

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear.

OBJECTIVES: To investigate overweight and changes in overweight status in children age 1 to 8 years in relation to asthma symptoms in childhood.

METHODS: We studied 3756 children who participated in a large birth cohort study. The parents reported their children's weight and height, and wheeze, dyspnea, and prescription of inhaled corticosteroids in yearly questionnaires. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years.

RESULTS: At 8 years, 275 children (7.3%) wheezed, 361 (9.6%) had dyspnea, and 268 (7.1%) had a prescription of inhaled corticosteroids in the preceding year. Children who had a persistent high body mass index (BMI, weight/height2) during childhood or a high BMI at 6 to 7 years had a significantly increased risk of dyspnea (adjusted odds ratio, 1.68; 95% CI, 1.18-2.39, for a high BMI at 6-7 years) and measured BHR (adjusted odds ratio, 1.66; 95% CI, 1.10-2.52) at 8 years. Children with a high BMI at a young age, but who developed a normal BMI at 6 to 7 years, did not have an increased risk of dyspnea or BHR at 8 years. BMI was not associated with sensitization.

CONCLUSION: Children with a current high BMI are at increased risk to have dyspnea and BHR at 8 years. A high BMI at an earlier age is not related to an increased risk if the child has become normal weight at 6 to 7 years.

Original language	English
Pages (from-to)	1312-1318.e2
Number of pages	9
Journal	Journal of Allergy and Clinical Immunology
Volume	123
Issue number	6
Early online date	5 May 2009
DOIs	https://doi.org/10.1016/j.jaci.2009.02.029
Publication status	Published - Jun 2009

Keywords

Adrenal Cortex Hormones
Allergens
Asthma
Body Mass Index
Body Weight
Child
Child, Preschool
Cohort Studies
Dyspnea
Female
Humans
Immunoglobulin E
Infant
Male
Netherlands
Overweight
Prevalence
Respiratory Sounds
Surveys and Questionnaires
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaci.2009.02.029

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@article{e3250c3f9244406884b1b784a68570df,

title = "Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age",

abstract = "BACKGROUND: Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear.OBJECTIVES: To investigate overweight and changes in overweight status in children age 1 to 8 years in relation to asthma symptoms in childhood.METHODS: We studied 3756 children who participated in a large birth cohort study. The parents reported their children's weight and height, and wheeze, dyspnea, and prescription of inhaled corticosteroids in yearly questionnaires. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years.RESULTS: At 8 years, 275 children (7.3%) wheezed, 361 (9.6%) had dyspnea, and 268 (7.1%) had a prescription of inhaled corticosteroids in the preceding year. Children who had a persistent high body mass index (BMI, weight/height2) during childhood or a high BMI at 6 to 7 years had a significantly increased risk of dyspnea (adjusted odds ratio, 1.68; 95% CI, 1.18-2.39, for a high BMI at 6-7 years) and measured BHR (adjusted odds ratio, 1.66; 95% CI, 1.10-2.52) at 8 years. Children with a high BMI at a young age, but who developed a normal BMI at 6 to 7 years, did not have an increased risk of dyspnea or BHR at 8 years. BMI was not associated with sensitization.CONCLUSION: Children with a current high BMI are at increased risk to have dyspnea and BHR at 8 years. A high BMI at an earlier age is not related to an increased risk if the child has become normal weight at 6 to 7 years.",

keywords = "Adrenal Cortex Hormones, Allergens, Asthma, Body Mass Index, Body Weight, Child, Child, Preschool, Cohort Studies, Dyspnea, Female, Humans, Immunoglobulin E, Infant, Male, Netherlands, Overweight, Prevalence, Respiratory Sounds, Surveys and Questionnaires, Journal Article, Research Support, Non-U.S. Gov't",

author = "Salome Scholtens and Wijga, {Alet H} and Seidell, {Jacob C} and Bert Brunekreef and {de Jongste}, {Johan C} and Ulrike Gehring and Postma, {Dirkje S} and Marjan Kerkhof and Smit, {Henriette A}",

year = "2009",

month = jun,

doi = "10.1016/j.jaci.2009.02.029",

language = "English",

volume = "123",

pages = "1312--1318.e2",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age

AU - Scholtens, Salome

AU - Wijga, Alet H

AU - Seidell, Jacob C

AU - Brunekreef, Bert

AU - de Jongste, Johan C

AU - Gehring, Ulrike

AU - Postma, Dirkje S

AU - Kerkhof, Marjan

AU - Smit, Henriette A

PY - 2009/6

Y1 - 2009/6

N2 - BACKGROUND: Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear.OBJECTIVES: To investigate overweight and changes in overweight status in children age 1 to 8 years in relation to asthma symptoms in childhood.METHODS: We studied 3756 children who participated in a large birth cohort study. The parents reported their children's weight and height, and wheeze, dyspnea, and prescription of inhaled corticosteroids in yearly questionnaires. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years.RESULTS: At 8 years, 275 children (7.3%) wheezed, 361 (9.6%) had dyspnea, and 268 (7.1%) had a prescription of inhaled corticosteroids in the preceding year. Children who had a persistent high body mass index (BMI, weight/height2) during childhood or a high BMI at 6 to 7 years had a significantly increased risk of dyspnea (adjusted odds ratio, 1.68; 95% CI, 1.18-2.39, for a high BMI at 6-7 years) and measured BHR (adjusted odds ratio, 1.66; 95% CI, 1.10-2.52) at 8 years. Children with a high BMI at a young age, but who developed a normal BMI at 6 to 7 years, did not have an increased risk of dyspnea or BHR at 8 years. BMI was not associated with sensitization.CONCLUSION: Children with a current high BMI are at increased risk to have dyspnea and BHR at 8 years. A high BMI at an earlier age is not related to an increased risk if the child has become normal weight at 6 to 7 years.

AB - BACKGROUND: Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear.OBJECTIVES: To investigate overweight and changes in overweight status in children age 1 to 8 years in relation to asthma symptoms in childhood.METHODS: We studied 3756 children who participated in a large birth cohort study. The parents reported their children's weight and height, and wheeze, dyspnea, and prescription of inhaled corticosteroids in yearly questionnaires. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years.RESULTS: At 8 years, 275 children (7.3%) wheezed, 361 (9.6%) had dyspnea, and 268 (7.1%) had a prescription of inhaled corticosteroids in the preceding year. Children who had a persistent high body mass index (BMI, weight/height2) during childhood or a high BMI at 6 to 7 years had a significantly increased risk of dyspnea (adjusted odds ratio, 1.68; 95% CI, 1.18-2.39, for a high BMI at 6-7 years) and measured BHR (adjusted odds ratio, 1.66; 95% CI, 1.10-2.52) at 8 years. Children with a high BMI at a young age, but who developed a normal BMI at 6 to 7 years, did not have an increased risk of dyspnea or BHR at 8 years. BMI was not associated with sensitization.CONCLUSION: Children with a current high BMI are at increased risk to have dyspnea and BHR at 8 years. A high BMI at an earlier age is not related to an increased risk if the child has become normal weight at 6 to 7 years.

KW - Adrenal Cortex Hormones

KW - Allergens

KW - Asthma

KW - Body Mass Index

KW - Body Weight

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Dyspnea

KW - Female

KW - Humans

KW - Immunoglobulin E

KW - Infant

KW - Male

KW - Netherlands

KW - Overweight

KW - Prevalence

KW - Respiratory Sounds

KW - Surveys and Questionnaires

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jaci.2009.02.029

DO - 10.1016/j.jaci.2009.02.029

M3 - Article

C2 - 19409606

SN - 0091-6749

VL - 123

SP - 1312-1318.e2

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 6

ER -

Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age

Abstract

Keywords

UN SDGs

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