Abstract
Although the oxytocin receptor gene (OXTR) is involved in aggression and social affiliation, it has not been examined in gene-environment interaction studies. This longitudinal study examined the effect of genetic variants in OXTR and its gene-environment interaction with perceived deviant peer affiliation in the trajectories of antisocial behavior in 323 adolescents (182 males) from 13 to 18 years. Annual assessments of reactive and proactive aggression, delinquency, and friends’ delinquency, as well as DNA at age 17 were collected. Gene-based tests yielded no main effect of OXTR, but revealed a significant gene-environment interaction in proactive aggression and delinquency. Variation in the OXTR might affect the influence of deviant peer affiliation on antisocial behavior, contributing to a better understanding of individual differences in antisocial behavior.
Original language | English |
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Pages (from-to) | 86-101 |
Number of pages | 16 |
Journal | Journal of Youth and Adolescence |
Volume | 48 |
Issue number | 1 |
Early online date | 12 Oct 2018 |
DOIs | |
Publication status | Published - 15 Jan 2019 |
Funding
Funding The RADAR-y project has been financially supported by grants from the Netherlands Organisation for Scientific Research (GB-MAGW 480-03-005,GB-MAGW 480-08-006), the Stichting Achmea Slachtoffer en Samenleving (SASS), a grant from the Netherlands Organisation for Scientific Research to the Consortium Individual Development (CID; 024.001.003), and several other grants from the Netherlands Organisation for Scientific Research, VU University Amsterdam, and Utrecht University.
Funders | Funder number |
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Stichting Achmea Slachtoffer en Samenleving | 024.001.003 |
Universiteit Utrecht | |
Vrije Universiteit Amsterdam | |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek | GB-MAGW 480-03-005, GB-MAGW 480-08-006 |
Keywords
- Antisocial behavior
- Deviant peer affiliation
- Gene-environment interaction
- Oxytocin receptor gene