TY - JOUR
T1 - Oxytocin Receptor Gene (OXTR) and Deviant Peer Affiliation
T2 - A Gene–Environment Interaction in Adolescent Antisocial Behavior
AU - Fragkaki, Iro
AU - Cima, Maaike
AU - Verhagen, Maaike
AU - Maciejewski, Dominique F.
AU - Boks, Marco P.
AU - van Lier, Pol A.C.
AU - Koot, Hans M.
AU - Branje, Susan J.T.
AU - Meeus, Wim H.J.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Although the oxytocin receptor gene (OXTR) is involved in aggression and social affiliation, it has not been examined in gene-environment interaction studies. This longitudinal study examined the effect of genetic variants in OXTR and its gene-environment interaction with perceived deviant peer affiliation in the trajectories of antisocial behavior in 323 adolescents (182 males) from 13 to 18 years. Annual assessments of reactive and proactive aggression, delinquency, and friends’ delinquency, as well as DNA at age 17 were collected. Gene-based tests yielded no main effect of OXTR, but revealed a significant gene-environment interaction in proactive aggression and delinquency. Variation in the OXTR might affect the influence of deviant peer affiliation on antisocial behavior, contributing to a better understanding of individual differences in antisocial behavior.
AB - Although the oxytocin receptor gene (OXTR) is involved in aggression and social affiliation, it has not been examined in gene-environment interaction studies. This longitudinal study examined the effect of genetic variants in OXTR and its gene-environment interaction with perceived deviant peer affiliation in the trajectories of antisocial behavior in 323 adolescents (182 males) from 13 to 18 years. Annual assessments of reactive and proactive aggression, delinquency, and friends’ delinquency, as well as DNA at age 17 were collected. Gene-based tests yielded no main effect of OXTR, but revealed a significant gene-environment interaction in proactive aggression and delinquency. Variation in the OXTR might affect the influence of deviant peer affiliation on antisocial behavior, contributing to a better understanding of individual differences in antisocial behavior.
KW - Antisocial behavior
KW - Deviant peer affiliation
KW - Gene-environment interaction
KW - Oxytocin receptor gene
UR - http://www.scopus.com/inward/record.url?scp=85055337546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055337546&partnerID=8YFLogxK
U2 - 10.1007/s10964-018-0939-x
DO - 10.1007/s10964-018-0939-x
M3 - Article
C2 - 30315439
AN - SCOPUS:85055337546
VL - 48
SP - 86
EP - 101
JO - Journal of Youth and Adolescence
JF - Journal of Youth and Adolescence
SN - 0047-2891
IS - 1
ER -
