Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

T. Vlaar, E. Ruijter, A. Znabett, E. Janssen, F.J.J. de Kanter, B.U.W. Maes, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review


Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.

Original languageEnglish
Pages (from-to)6496-6499
Number of pages4
JournalOrganic letters
Issue number24
Publication statusPublished - 15 Nov 2011


  • Catalysis
  • Molecular Structure
  • Nitriles/chemistry
  • Palladium/chemistry
  • Phthalazines/chemical synthesis
  • Stereoisomerism


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