Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

T. Vlaar; E. Ruijter; A. Znabett; E. Janssen; F.J.J. de Kanter; B.U.W. Maes; R.V.A. Orru

doi:10.1021/ol202784d

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

T. Vlaar
, E. Ruijter
, A. Znabett
, E. Janssen
, F.J.J. de Kanter
, B.U.W. Maes
, R.V.A. Orru

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.

Original language	English
Pages (from-to)	6496-6499
Number of pages	4
Journal	Organic letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1021/ol202784d
Publication status	Published - 15 Nov 2011

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SDG 6 Clean Water and Sanitation

Keywords

Catalysis
Molecular Structure
Nitriles/chemistry
Palladium/chemistry
Phthalazines/chemical synthesis
Stereoisomerism

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10.1021/ol202784d

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title = "Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion",

abstract = "Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.",

keywords = "Catalysis, Molecular Structure, Nitriles/chemistry, Palladium/chemistry, Phthalazines/chemical synthesis, Stereoisomerism",

author = "T. Vlaar and E. Ruijter and A. Znabett and E. Janssen and \{de Kanter\}, F.J.J. and B.U.W. Maes and R.V.A. Orru",

year = "2011",

month = nov,

day = "15",

doi = "10.1021/ol202784d",

language = "English",

volume = "13",

pages = "6496--6499",

journal = "Organic letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "24",

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TY - JOUR

T1 - Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

AU - Vlaar, T.

AU - Ruijter, E.

AU - Znabett, A.

AU - Janssen, E.

AU - de Kanter, F.J.J.

AU - Maes, B.U.W.

AU - Orru, R.V.A.

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.

AB - Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.

KW - Catalysis

KW - Molecular Structure

KW - Nitriles/chemistry

KW - Palladium/chemistry

KW - Phthalazines/chemical synthesis

KW - Stereoisomerism

U2 - 10.1021/ol202784d

DO - 10.1021/ol202784d

M3 - Article

C2 - 22085248

SN - 1523-7060

VL - 13

SP - 6496

EP - 6499

JO - Organic letters

JF - Organic letters

IS - 24

ER -

Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion

Abstract

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Keywords

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