Pallidal low‐frequency activity in dystonia after cessation of long‐term deep brain stimulation

Ute Scheller; Roxanne Lofredi; B. C. M. van Wijk; Assel Saryyeva; Joachim K. Krauss; Gerd‐Helge Schneider; Daniel Kroneberg; Patricia Krause; Wolf‐Julian Neumann; Andrea A. Kühn

doi:10.1002/mds.27838

Pallidal low‐frequency activity in dystonia after cessation of long‐term deep brain stimulation

Ute Scheller
, Roxanne Lofredi
, B. C. M. van Wijk
, Assel Saryyeva
, Joachim K. Krauss
, Gerd‐Helge Schneider
, Daniel Kroneberg
, Patricia Krause
, Wolf‐Julian Neumann
, Andrea A. Kühn

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective

This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months.
Methods

Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1–T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3–12 Hz) and beta range (13–30 Hz).
Results

A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3–12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3–7.5), but not beta activity (13–30 Hz) was revealed within participants across timepoints.
Conclusion

Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 Charité. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson andMovement Disorder Society

Original language	Undefined/Unknown
Pages (from-to)	1734-1739
Number of pages	6
Journal	Movement Disorders
Volume	34
Issue number	11
Early online date	4 Sept 2019
DOIs	https://doi.org/10.1002/mds.27838
Publication status	Published - Nov 2019
Externally published	Yes

Funding

agencies: German Research Council Grant KFO247.This study was funded by the German Research Foundation Deutsche Forschungsgemeinschaft (Grant KFO247). Medtronic provided the PC + S pulse generators for this study. We thank Gaetano Leogrande from Medtronic for technical advice on the local field potential recordings.

Funders	Funder number
German Research Foundation Deutsche Forschungsgemeinschaft	KFO247
Medtronic
Deutsche Forschungsgemeinschaft

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10.1002/mds.27838Licence: CC BY-NC-ND

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Cite this

@article{7f989a99c59a4254ba8bb6dc11a716f9,

title = "Pallidal low‐frequency activity in dystonia after cessation of long‐term deep brain stimulation",

abstract = " Objective This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. Methods Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1–T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3–12 Hz) and beta range (13–30 Hz). Results A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3–12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95\% confidence interval, 1.3–7.5), but not beta activity (13–30 Hz) was revealed within participants across timepoints. Conclusion Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. {\textcopyright} 2019 Charit{\'e}. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson andMovement Disorder Society ",

author = "Ute Scheller and Roxanne Lofredi and \{van Wijk\}, \{B. C. M.\} and Assel Saryyeva and Krauss, \{Joachim K.\} and Gerd‐Helge Schneider and Daniel Kroneberg and Patricia Krause and Wolf‐Julian Neumann and K{\"u}hn, \{Andrea A.\}",

year = "2019",

month = nov,

doi = "10.1002/mds.27838",

language = "Undefined/Unknown",

volume = "34",

pages = "1734--1739",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Pallidal low‐frequency activity in dystonia after cessation of long‐term deep brain stimulation

AU - Scheller, Ute

AU - Lofredi, Roxanne

AU - van Wijk, B. C. M.

AU - Saryyeva, Assel

AU - Krauss, Joachim K.

AU - Schneider, Gerd‐Helge

AU - Kroneberg, Daniel

AU - Krause, Patricia

AU - Neumann, Wolf‐Julian

AU - Kühn, Andrea A.

PY - 2019/11

Y1 - 2019/11

N2 - Objective This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. Methods Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1–T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3–12 Hz) and beta range (13–30 Hz). Results A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3–12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3–7.5), but not beta activity (13–30 Hz) was revealed within participants across timepoints. Conclusion Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 Charité. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson andMovement Disorder Society

AB - Objective This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. Methods Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1–T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3–12 Hz) and beta range (13–30 Hz). Results A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3–12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3–7.5), but not beta activity (13–30 Hz) was revealed within participants across timepoints. Conclusion Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 Charité. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson andMovement Disorder Society

U2 - 10.1002/mds.27838

DO - 10.1002/mds.27838

M3 - Article

SN - 0885-3185

VL - 34

SP - 1734

EP - 1739

JO - Movement Disorders

JF - Movement Disorders

IS - 11

ER -