TY - JOUR
T1 - Parent of origin effects in attention/deficit hyperacticvity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program
AU - Anney, R.J.
AU - Hawi, Z.
AU - Sheehan, K.
AU - Mulligan, A.
AU - Pinto, C.
AU - Brookes, K
AU - Xu, X.
AU - Zhou, K.
AU - Franke, B.
AU - Buitelaar, J.
AU - Vermeulen, S.H.
AU - Banaschewski, T.
AU - Sonuga-Barke, E.J.S.
AU - Thompson, M.
AU - Sergeant, J.A.
AU - Asherson, P.
AU - Faraone, S.V.
PY - 2008
Y1 - 2008
N2 - Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 × 10
AB - Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 × 10
U2 - 10.1002/ajmg.b.30871
DO - 10.1002/ajmg.b.30871
M3 - Article
VL - 147B
SP - 1369
EP - 1378
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 8
ER -
