Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts

Karri Silventoinen*, Aline Jelenkovic, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Sari Aaltonen, Maarit Piirtola, Duarte L. Freitas, José A. Maia, Sevgi Y. Öncel, Fazil Aliev, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Kimberly J. Saudino, Tessa L. CutlerJohn L. Hopper, Vilhelmina Ullemar, Catarina Almqvist, Patrik K.E. Magnusson, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Gonneke Willemsen, Meike Bartels, Catharina E.M. van Beijsterveldt, Tracy L. Nelson, Keith E. Whitfield, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Clare H. Llewellyn, Abigail Fisher, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Laura A. Baker, Catherine Tuvblad, Robin P. Corley, Brooke M. Huibregtse, Catherine A. Derom, Robert F. Vlietinck, Ruth J.F. Loos, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S. Alexandra Burt, Kelly L. Klump, Judy L. Silberg, Hermine H. Maes, Robert F. Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A. Butler, Jennifer R. Harris, Thomas S. Nilsen, K. Paige Harden, Elliot M. Tucker-Drob, Carol E. Franz, William S. Kremen, Michael J. Lyons, Paul Lichtenstein, Hoe Uk Jeong, Yoon Mi Hur, Dorret I. Boomsma, Thorkild I.A. Sørensen, Jaakko Kaprio

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.

METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.

RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.

CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

Original languageEnglish
Pages (from-to)855-865
Number of pages11
JournalObesity
Volume27
Issue number5
Early online date5 Apr 2019
DOIs
Publication statusPublished - May 2019

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    Silventoinen, K., Jelenkovic, A., Latvala, A., Yokoyama, Y., Sund, R., Sugawara, M., ... Kaprio, J. (2019). Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. Obesity, 27(5), 855-865. https://doi.org/10.1002/oby.22451