Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts

Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Sari Aaltonen, Maarit Piirtola, Duarte L Freitas, José A Maia, Sevgi Y Öncel, Fazil Aliev, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Kimberly J Saudino, Tessa L Cutler & 53 others John L Hopper, Vilhelmina Ullemar, Catarina Almqvist, Patrik K E Magnusson, Wendy Cozen, Amie E Hwang, Thomas M Mack, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveldt, Tracy L Nelson, Keith E Whitfield, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Clare H Llewellyn, Abigail Fisher, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Laura A Baker, Catherine Tuvblad, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Judy L Silberg, Hermine H Maes, Robert F Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A Butler, Jennifer R Harris, Thomas S Nilsen, K Paige Harden, Elliot M Tucker-Drob, Carol E Franz, William S Kremen, Michael J Lyons, Paul Lichtenstein, Hoe-Uk Jeong, Yoon-Mi Hur, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.

METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.

RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.

CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

LanguageEnglish
Pages855-865
Number of pages11
JournalObesity
Volume27
Issue number5
DOIs
Publication statusPublished - May 2019

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Education
Parents
Far East
Social Environment
Genetic Predisposition to Disease
North America

Bibliographical note

© 2019 The Obesity Society.

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Silventoinen, K., Jelenkovic, A., Latvala, A., Yokoyama, Y., Sund, R., Sugawara, M., ... Kaprio, J. (2019). Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. Obesity, 27(5), 855-865. https://doi.org/10.1002/oby.22451
Silventoinen, Karri ; Jelenkovic, Aline ; Latvala, Antti ; Yokoyama, Yoshie ; Sund, Reijo ; Sugawara, Masumi ; Tanaka, Mami ; Matsumoto, Satoko ; Aaltonen, Sari ; Piirtola, Maarit ; Freitas, Duarte L ; Maia, José A ; Öncel, Sevgi Y ; Aliev, Fazil ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Rebato, Esther ; Saudino, Kimberly J ; Cutler, Tessa L ; Hopper, John L ; Ullemar, Vilhelmina ; Almqvist, Catarina ; Magnusson, Patrik K E ; Cozen, Wendy ; Hwang, Amie E ; Mack, Thomas M ; Willemsen, Gonneke ; Bartels, Meike ; van Beijsterveldt, Catharina E M ; Nelson, Tracy L ; Whitfield, Keith E ; Sung, Joohon ; Kim, Jina ; Lee, Jooyeon ; Lee, Sooji ; Llewellyn, Clare H ; Fisher, Abigail ; Medda, Emanuela ; Nisticò, Lorenza ; Toccaceli, Virgilia ; Baker, Laura A ; Tuvblad, Catherine ; Corley, Robin P ; Huibregtse, Brooke M ; Derom, Catherine A ; Vlietinck, Robert F ; Loos, Ruth J F ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Burt, S Alexandra ; Klump, Kelly L ; Silberg, Judy L ; Maes, Hermine H ; Krueger, Robert F ; McGue, Matt ; Pahlen, Shandell ; Gatz, Margaret ; Butler, David A ; Harris, Jennifer R ; Nilsen, Thomas S ; Harden, K Paige ; Tucker-Drob, Elliot M ; Franz, Carol E ; Kremen, William S ; Lyons, Michael J ; Lichtenstein, Paul ; Jeong, Hoe-Uk ; Hur, Yoon-Mi ; Boomsma, Dorret I ; Sørensen, Thorkild I A ; Kaprio, Jaakko. / Parental Education and Genetics of BMI from Infancy to Old Age : A Pooled Analysis of 29 Twin Cohorts. In: Obesity. 2019 ; Vol. 27, No. 5. pp. 855-865.
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abstract = "OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.",
author = "Karri Silventoinen and Aline Jelenkovic and Antti Latvala and Yoshie Yokoyama and Reijo Sund and Masumi Sugawara and Mami Tanaka and Satoko Matsumoto and Sari Aaltonen and Maarit Piirtola and Freitas, {Duarte L} and Maia, {Jos{\'e} A} and {\"O}ncel, {Sevgi Y} and Fazil Aliev and Fuling Ji and Feng Ning and Zengchang Pang and Esther Rebato and Saudino, {Kimberly J} and Cutler, {Tessa L} and Hopper, {John L} and Vilhelmina Ullemar and Catarina Almqvist and Magnusson, {Patrik K E} and Wendy Cozen and Hwang, {Amie E} and Mack, {Thomas M} and Gonneke Willemsen and Meike Bartels and {van Beijsterveldt}, {Catharina E M} and Nelson, {Tracy L} and Whitfield, {Keith E} and Joohon Sung and Jina Kim and Jooyeon Lee and Sooji Lee and Llewellyn, {Clare H} and Abigail Fisher and Emanuela Medda and Lorenza Nistic{\`o} and Virgilia Toccaceli and Baker, {Laura A} and Catherine Tuvblad and Corley, {Robin P} and Huibregtse, {Brooke M} and Derom, {Catherine A} and Vlietinck, {Robert F} and Loos, {Ruth J F} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Burt, {S Alexandra} and Klump, {Kelly L} and Silberg, {Judy L} and Maes, {Hermine H} and Krueger, {Robert F} and Matt McGue and Shandell Pahlen and Margaret Gatz and Butler, {David A} and Harris, {Jennifer R} and Nilsen, {Thomas S} and Harden, {K Paige} and Tucker-Drob, {Elliot M} and Franz, {Carol E} and Kremen, {William S} and Lyons, {Michael J} and Paul Lichtenstein and Hoe-Uk Jeong and Yoon-Mi Hur and Boomsma, {Dorret I} and S{\o}rensen, {Thorkild I A} and Jaakko Kaprio",
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Silventoinen, K, Jelenkovic, A, Latvala, A, Yokoyama, Y, Sund, R, Sugawara, M, Tanaka, M, Matsumoto, S, Aaltonen, S, Piirtola, M, Freitas, DL, Maia, JA, Öncel, SY, Aliev, F, Ji, F, Ning, F, Pang, Z, Rebato, E, Saudino, KJ, Cutler, TL, Hopper, JL, Ullemar, V, Almqvist, C, Magnusson, PKE, Cozen, W, Hwang, AE, Mack, TM, Willemsen, G, Bartels, M, van Beijsterveldt, CEM, Nelson, TL, Whitfield, KE, Sung, J, Kim, J, Lee, J, Lee, S, Llewellyn, CH, Fisher, A, Medda, E, Nisticò, L, Toccaceli, V, Baker, LA, Tuvblad, C, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Harris, JR, Nilsen, TS, Harden, KP, Tucker-Drob, EM, Franz, CE, Kremen, WS, Lyons, MJ, Lichtenstein, P, Jeong, H-U, Hur, Y-M, Boomsma, DI, Sørensen, TIA & Kaprio, J 2019, 'Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts', Obesity, vol. 27, no. 5, pp. 855-865. https://doi.org/10.1002/oby.22451

Parental Education and Genetics of BMI from Infancy to Old Age : A Pooled Analysis of 29 Twin Cohorts. / Silventoinen, Karri; Jelenkovic, Aline; Latvala, Antti; Yokoyama, Yoshie; Sund, Reijo; Sugawara, Masumi; Tanaka, Mami; Matsumoto, Satoko; Aaltonen, Sari; Piirtola, Maarit; Freitas, Duarte L; Maia, José A; Öncel, Sevgi Y; Aliev, Fazil; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Saudino, Kimberly J; Cutler, Tessa L; Hopper, John L; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K E; Cozen, Wendy; Hwang, Amie E; Mack, Thomas M; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Catharina E M; Nelson, Tracy L; Whitfield, Keith E; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Llewellyn, Clare H; Fisher, Abigail; Medda, Emanuela; Nisticò, Lorenza; Toccaceli, Virgilia; Baker, Laura A; Tuvblad, Catherine; Corley, Robin P; Huibregtse, Brooke M; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth J F; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Burt, S Alexandra; Klump, Kelly L; Silberg, Judy L; Maes, Hermine H; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A; Harris, Jennifer R; Nilsen, Thomas S; Harden, K Paige; Tucker-Drob, Elliot M; Franz, Carol E; Kremen, William S; Lyons, Michael J; Lichtenstein, Paul; Jeong, Hoe-Uk; Hur, Yoon-Mi; Boomsma, Dorret I; Sørensen, Thorkild I A; Kaprio, Jaakko.

In: Obesity, Vol. 27, No. 5, 05.2019, p. 855-865.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Parental Education and Genetics of BMI from Infancy to Old Age

T2 - Obesity

AU - Silventoinen, Karri

AU - Jelenkovic, Aline

AU - Latvala, Antti

AU - Yokoyama, Yoshie

AU - Sund, Reijo

AU - Sugawara, Masumi

AU - Tanaka, Mami

AU - Matsumoto, Satoko

AU - Aaltonen, Sari

AU - Piirtola, Maarit

AU - Freitas, Duarte L

AU - Maia, José A

AU - Öncel, Sevgi Y

AU - Aliev, Fazil

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Rebato, Esther

AU - Saudino, Kimberly J

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Ullemar, Vilhelmina

AU - Almqvist, Catarina

AU - Magnusson, Patrik K E

AU - Cozen, Wendy

AU - Hwang, Amie E

AU - Mack, Thomas M

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, Catharina E M

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Sung, Joohon

AU - Kim, Jina

AU - Lee, Jooyeon

AU - Lee, Sooji

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - Medda, Emanuela

AU - Nisticò, Lorenza

AU - Toccaceli, Virgilia

AU - Baker, Laura A

AU - Tuvblad, Catherine

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth J F

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Silberg, Judy L

AU - Maes, Hermine H

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Gatz, Margaret

AU - Butler, David A

AU - Harris, Jennifer R

AU - Nilsen, Thomas S

AU - Harden, K Paige

AU - Tucker-Drob, Elliot M

AU - Franz, Carol E

AU - Kremen, William S

AU - Lyons, Michael J

AU - Lichtenstein, Paul

AU - Jeong, Hoe-Uk

AU - Hur, Yoon-Mi

AU - Boomsma, Dorret I

AU - Sørensen, Thorkild I A

AU - Kaprio, Jaakko

N1 - © 2019 The Obesity Society.

PY - 2019/5

Y1 - 2019/5

N2 - OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

AB - OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

U2 - 10.1002/oby.22451

DO - 10.1002/oby.22451

M3 - Article

VL - 27

SP - 855

EP - 865

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -

Silventoinen K, Jelenkovic A, Latvala A, Yokoyama Y, Sund R, Sugawara M et al. Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. Obesity. 2019 May;27(5):855-865. https://doi.org/10.1002/oby.22451