Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

K.M. Smeele, O. Eerbeek, A. Koeman, R. Bezemer, C. Ince, S. Heikkinen, M. Laakso, A. de Haan, G. Schaart, M.R. Drost, M.W. Hollmann, C.J. Zuurbier

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    Abstract

    Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute ischemia-reperfusion injury in skeletal muscle of the intact animal. Male and female heterozygote knockout HKII (HK
    Original languageEnglish
    Pages (from-to)705-712
    JournalPflügers Archiv European Journal of Physiology
    Volume459
    Issue number5
    DOIs
    Publication statusPublished - 2010

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