Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

K.M. Smeele; O. Eerbeek; A. Koeman; R. Bezemer; C. Ince; S. Heikkinen; M. Laakso; A. de Haan; G. Schaart; M.R. Drost; M.W. Hollmann; C.J. Zuurbier

doi:10.1007/s00424-010-0787-3

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

K.M. Smeele, O. Eerbeek, A. Koeman, R. Bezemer, C. Ince, S. Heikkinen, M. Laakso, A. de Haan, G. Schaart, M.R. Drost, M.W. Hollmann, C.J. Zuurbier

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Abstract

Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute ischemia-reperfusion injury in skeletal muscle of the intact animal. Male and female heterozygote knockout HKII (HK

Original language	English
Pages (from-to)	705-712
Journal	Pflügers Archiv European Journal of Physiology
Volume	459
Issue number	5
DOIs	https://doi.org/10.1007/s00424-010-0787-3
Publication status	Published - 2010

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Smeele, K. M., Eerbeek, O., Koeman, A., Bezemer, R., Ince, C., Heikkinen, S., Laakso, M., de Haan, A., Schaart, G., Drost, M. R., Hollmann, M. W., & Zuurbier, C. J. (2010). Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice. Pflügers Archiv European Journal of Physiology, 459(5), 705-712. https://doi.org/10.1007/s00424-010-0787-3

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title = "Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice",

abstract = "Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute ischemia-reperfusion injury in skeletal muscle of the intact animal. Male and female heterozygote knockout HKII (HK",

author = "K.M. Smeele and O. Eerbeek and A. Koeman and R. Bezemer and C. Ince and S. Heikkinen and M. Laakso and {de Haan}, A. and G. Schaart and M.R. Drost and M.W. Hollmann and C.J. Zuurbier",

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Smeele, KM, Eerbeek, O, Koeman, A, Bezemer, R, Ince, C, Heikkinen, S, Laakso, M, de Haan, A, Schaart, G, Drost, MR, Hollmann, MW & Zuurbier, CJ 2010, 'Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice', Pflügers Archiv European Journal of Physiology, vol. 459, no. 5, pp. 705-712. https://doi.org/10.1007/s00424-010-0787-3

TY - JOUR

T1 - Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

AU - Smeele, K.M.

AU - Eerbeek, O.

AU - Koeman, A.

AU - Bezemer, R.

AU - Ince, C.

AU - Heikkinen, S.

AU - Laakso, M.

AU - de Haan, A.

AU - Schaart, G.

AU - Drost, M.R.

AU - Hollmann, M.W.

AU - Zuurbier, C.J.

PY - 2010

Y1 - 2010

N2 - Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute ischemia-reperfusion injury in skeletal muscle of the intact animal. Male and female heterozygote knockout HKII (HK

AB - Cellular studies have demonstrated a protective role of mitochondrial hexokinase against oxidative insults. It is unknown whether HK protective effects translate to the in vivo condition. In the present study, we hypothesize that HK affects acute ischemia-reperfusion injury in skeletal muscle of the intact animal. Male and female heterozygote knockout HKII (HK

U2 - 10.1007/s00424-010-0787-3

DO - 10.1007/s00424-010-0787-3

M3 - Article

VL - 459

SP - 705

EP - 712

JO - Pflügers Archiv European Journal of Physiology

JF - Pflügers Archiv European Journal of Physiology

SN - 0031-6768

IS - 5

ER -

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

Abstract

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