Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.

A. Gusev, S.H. Lee, G. Trynka, H. Finucane, B.J. Vilhjálmsson, H. Xu, Z. Zang, S. Ripke, B.K. Bulik-Sullivan, E. Stahl, A.K. Kähler, C. M. Hultman, S.M. Purcell, S.A. McCarroll, M. Daly, B. Pasaniuc, P.F. Sullivan, B.M. Neale, N.R. Wray, S. RaychaudhuriA.L. Price

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common diseases to partition the heritability explained by genotyped SNPs (h
Original languageEnglish
Pages (from-to)535-552
JournalAmerican Journal of Human Genetics
Volume95
Issue number5
DOIs
Publication statusPublished - 2014

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