Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study

Rebecca T. Karsten; Michiel W.M. van den Brekel; Ludi E. Smeele; Arash Navran; Sam Leary; Kate Ingarfield; Michael Pawlita; Tim Waterboer; Steve J. Thomas; Andy R. Ness

doi:10.1002/hed.26131

Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study

Rebecca T. Karsten, Michiel W.M. van den Brekel, Ludi E. Smeele, Arash Navran, Sam Leary, Kate Ingarfield, Michael Pawlita, Tim Waterboer, Steve J. Thomas, Andy R. Ness

Maxillofacial Surgery (AMC)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Single-modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early-stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self-reported swallowing function. Methods: Participants with a T1-2N0-2bM0 OPC who were offered single-modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self-reported swallowing function was compared between surgery and RT. Results: Those offered RT (n = 150) had less favorable baseline characteristics than those offered surgery (n = 150). At 12-month follow up, RT participants reported more swallowing problems (35% vs 23%, RR 1.3; 95% CI 0.8-2.3, P =.277) in models adjusted for baseline characteristics. In those allocated to surgery who received adjuvant therapy (n = 78, 52%), the proportion with swallowing problems was similar to those allocated to RT alone. Conclusions: Participants offered surgery alone had similar mortality but improved swallowing, although this was not statistically significant. However, over half of participants offered surgery alone received surgery and adjuvant therapy.

Original language	English
Pages (from-to)	1981-1993
Number of pages	13
Journal	Head and Neck
Volume	42
Issue number	8
DOIs	https://doi.org/10.1002/hed.26131
Publication status	Published - Aug 2020

Funding

This publication presents data from the HN5000 study that was a component of independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Scheme (RP-PG-0707-10034). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Human papillomavirus (HPV) serology was supported by a Cancer Research UK Programme Grant, the Integrative Cancer Epidemiology Programme (grant number: C18281/A19169). The department of Head and Neck Oncology and Surgery of the Netherlands Cancer Institute receives a research grant from ATOS Medical to support this type of research. We thank Vanessa Marshall, Katrina Hurley, and Tom Stu for their contribution to the project.

Funders	Funder number
Integrative Cancer Epidemiology Programme	C18281/A19169
National Institute for Health Research	RP-PG-0707-10034
Cancer Research UK

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study",

abstract = "Background: Single-modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early-stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self-reported swallowing function. Methods: Participants with a T1-2N0-2bM0 OPC who were offered single-modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self-reported swallowing function was compared between surgery and RT. Results: Those offered RT (n = 150) had less favorable baseline characteristics than those offered surgery (n = 150). At 12-month follow up, RT participants reported more swallowing problems (35% vs 23%, RR 1.3; 95% CI 0.8-2.3, P =.277) in models adjusted for baseline characteristics. In those allocated to surgery who received adjuvant therapy (n = 78, 52%), the proportion with swallowing problems was similar to those allocated to RT alone. Conclusions: Participants offered surgery alone had similar mortality but improved swallowing, although this was not statistically significant. However, over half of participants offered surgery alone received surgery and adjuvant therapy.",

author = "Karsten, {Rebecca T.} and {van den Brekel}, {Michiel W.M.} and Smeele, {Ludi E.} and Arash Navran and Sam Leary and Kate Ingarfield and Michael Pawlita and Tim Waterboer and Thomas, {Steve J.} and Ness, {Andy R.}",

year = "2020",

month = aug,

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T1 - Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study

AU - Karsten, Rebecca T.

AU - van den Brekel, Michiel W.M.

AU - Smeele, Ludi E.

AU - Navran, Arash

AU - Leary, Sam

AU - Ingarfield, Kate

AU - Pawlita, Michael

AU - Waterboer, Tim

AU - Thomas, Steve J.

AU - Ness, Andy R.

PY - 2020/8

Y1 - 2020/8

N2 - Background: Single-modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early-stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self-reported swallowing function. Methods: Participants with a T1-2N0-2bM0 OPC who were offered single-modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self-reported swallowing function was compared between surgery and RT. Results: Those offered RT (n = 150) had less favorable baseline characteristics than those offered surgery (n = 150). At 12-month follow up, RT participants reported more swallowing problems (35% vs 23%, RR 1.3; 95% CI 0.8-2.3, P =.277) in models adjusted for baseline characteristics. In those allocated to surgery who received adjuvant therapy (n = 78, 52%), the proportion with swallowing problems was similar to those allocated to RT alone. Conclusions: Participants offered surgery alone had similar mortality but improved swallowing, although this was not statistically significant. However, over half of participants offered surgery alone received surgery and adjuvant therapy.

AB - Background: Single-modality treatment (surgery or radiotherapy [RT]) is a curative treatment option for early-stage oropharyngeal carcinoma (OPC) with comparable (excellent) oncological outcomes. This study aimed to compare self-reported swallowing function. Methods: Participants with a T1-2N0-2bM0 OPC who were offered single-modality treatment and were recruited to the Head and Neck 5000 study were included. Prospectively collected self-reported swallowing function was compared between surgery and RT. Results: Those offered RT (n = 150) had less favorable baseline characteristics than those offered surgery (n = 150). At 12-month follow up, RT participants reported more swallowing problems (35% vs 23%, RR 1.3; 95% CI 0.8-2.3, P =.277) in models adjusted for baseline characteristics. In those allocated to surgery who received adjuvant therapy (n = 78, 52%), the proportion with swallowing problems was similar to those allocated to RT alone. Conclusions: Participants offered surgery alone had similar mortality but improved swallowing, although this was not statistically significant. However, over half of participants offered surgery alone received surgery and adjuvant therapy.

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DO - 10.1002/hed.26131

M3 - Article

C2 - 32141678

SN - 1043-3074

VL - 42

SP - 1981

EP - 1993

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study

Abstract

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UN SDGs

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