Timen A. A patient with a biting or needlestick injury. Huisarts Wet 2013;56(11):578-83. Needlestick injuries cover those situations in which a person is exposed to the blood or another potentially infectious body fluid from a percutaneous wound in another person, such as a bite. The most important transmissible viruses are hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV): the likelihood of HBV transmission is by far the greatest. This articles reviews what steps should be taken to prevent infection after a needlestick injury. A good, structured patient history and systematic investigation of the immune status of the source and the affected individual are essential for post-exposure management. If the source is not known, prevalence data for different risk groups are important for risk assessment.