Pediatric traumatic brain injury affects multisensory integration

Marsh Königs, Wouter D. Weeda, L. W.Ernest van Heurn, R. Jeroen Vermeulen, J. Carel Goslings, Jan S.K. Luitse, Bwee Tien Poll-The, Anita Beelen, Marleen van der Wees, Rachèl J.J.K. Kemps, Coriene E. Catsman-Berrevoets, Jaap Oosterlaan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

To investigate the impact of pediatric traumatic brain injury (TBI) on multisensory integration in relation to general neurocognitive functioning. Method: Children with a hospital admission for TBI aged between 6 and 13 years (n = 94) were compared with children with trauma control (TC) injuries (n = 39), while differentiating between mild TBI without risk factors for complicated TBI (mildRF-; n = 19), mild TBI with ≥1 risk factor (mildRF+; n = 45), and moderate/severe TBI (n = 30). We measured set-shifting performance based on visual information (visual shift condition) and set-shifting performance based on audiovisual information, requiring multisensory integration (audiovisual shift condition). Effects of TBI on set-shifting performance were traced back to task strategy (i.e., boundary separation), processing efficiency (i.e., drift rate), or extradecisional processes (i.e., nondecision time) using diffusion model analysis. General neurocognitive functioning was measured using estimated full-scale IQ (FSIQ). Results: The TBI group showed selectively reduced performance in the audiovisual shift condition (p = .009, Cohen's d = -0.51). Follow-up analyses in the audiovisual shift condition revealed reduced performance in the mildRF+ TBI group and moderate/severe TBI group (ps ≤ .025, ds ≤ -0.61). These effects were traced back to lower drift rate (ps ≤ .048, ds ≤ -0.44), reflecting reduced multisensory integration efficiency. Notably, accuracy and drift rate in the audiovisual shift condition partially mediated the relation between TBI and FSIQ. Conclusion: Children with mildRF+ or moderate/severe TBI are at risk for reduced multisensory integration efficiency, possibly contributing to decreased general neurocognitive functioning.

Original languageEnglish
Pages (from-to)137-148
Number of pages12
JournalNeuropsychology
Volume31
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

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Pediatrics
Brain Concussion
Traumatic Brain Injury
Wounds and Injuries

Keywords

  • General neurocognitive functioning
  • Multisensory integration
  • Pediatrics
  • Traumatic brain injury

Cite this

Königs, M., Weeda, W. D., van Heurn, L. W. E., Vermeulen, R. J., Goslings, J. C., Luitse, J. S. K., ... Oosterlaan, J. (2017). Pediatric traumatic brain injury affects multisensory integration. Neuropsychology, 31(2), 137-148. https://doi.org/10.1037/neu0000302
Königs, Marsh ; Weeda, Wouter D. ; van Heurn, L. W.Ernest ; Vermeulen, R. Jeroen ; Goslings, J. Carel ; Luitse, Jan S.K. ; Poll-The, Bwee Tien ; Beelen, Anita ; van der Wees, Marleen ; Kemps, Rachèl J.J.K. ; Catsman-Berrevoets, Coriene E. ; Oosterlaan, Jaap. / Pediatric traumatic brain injury affects multisensory integration. In: Neuropsychology. 2017 ; Vol. 31, No. 2. pp. 137-148.
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abstract = "To investigate the impact of pediatric traumatic brain injury (TBI) on multisensory integration in relation to general neurocognitive functioning. Method: Children with a hospital admission for TBI aged between 6 and 13 years (n = 94) were compared with children with trauma control (TC) injuries (n = 39), while differentiating between mild TBI without risk factors for complicated TBI (mildRF-; n = 19), mild TBI with ≥1 risk factor (mildRF+; n = 45), and moderate/severe TBI (n = 30). We measured set-shifting performance based on visual information (visual shift condition) and set-shifting performance based on audiovisual information, requiring multisensory integration (audiovisual shift condition). Effects of TBI on set-shifting performance were traced back to task strategy (i.e., boundary separation), processing efficiency (i.e., drift rate), or extradecisional processes (i.e., nondecision time) using diffusion model analysis. General neurocognitive functioning was measured using estimated full-scale IQ (FSIQ). Results: The TBI group showed selectively reduced performance in the audiovisual shift condition (p = .009, Cohen's d = -0.51). Follow-up analyses in the audiovisual shift condition revealed reduced performance in the mildRF+ TBI group and moderate/severe TBI group (ps ≤ .025, ds ≤ -0.61). These effects were traced back to lower drift rate (ps ≤ .048, ds ≤ -0.44), reflecting reduced multisensory integration efficiency. Notably, accuracy and drift rate in the audiovisual shift condition partially mediated the relation between TBI and FSIQ. Conclusion: Children with mildRF+ or moderate/severe TBI are at risk for reduced multisensory integration efficiency, possibly contributing to decreased general neurocognitive functioning.",
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Königs, M, Weeda, WD, van Heurn, LWE, Vermeulen, RJ, Goslings, JC, Luitse, JSK, Poll-The, BT, Beelen, A, van der Wees, M, Kemps, RJJK, Catsman-Berrevoets, CE & Oosterlaan, J 2017, 'Pediatric traumatic brain injury affects multisensory integration' Neuropsychology, vol. 31, no. 2, pp. 137-148. https://doi.org/10.1037/neu0000302

Pediatric traumatic brain injury affects multisensory integration. / Königs, Marsh; Weeda, Wouter D.; van Heurn, L. W.Ernest; Vermeulen, R. Jeroen; Goslings, J. Carel; Luitse, Jan S.K.; Poll-The, Bwee Tien; Beelen, Anita; van der Wees, Marleen; Kemps, Rachèl J.J.K.; Catsman-Berrevoets, Coriene E.; Oosterlaan, Jaap.

In: Neuropsychology, Vol. 31, No. 2, 01.02.2017, p. 137-148.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Königs, Marsh

AU - Weeda, Wouter D.

AU - van Heurn, L. W.Ernest

AU - Vermeulen, R. Jeroen

AU - Goslings, J. Carel

AU - Luitse, Jan S.K.

AU - Poll-The, Bwee Tien

AU - Beelen, Anita

AU - van der Wees, Marleen

AU - Kemps, Rachèl J.J.K.

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AU - Oosterlaan, Jaap

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N2 - To investigate the impact of pediatric traumatic brain injury (TBI) on multisensory integration in relation to general neurocognitive functioning. Method: Children with a hospital admission for TBI aged between 6 and 13 years (n = 94) were compared with children with trauma control (TC) injuries (n = 39), while differentiating between mild TBI without risk factors for complicated TBI (mildRF-; n = 19), mild TBI with ≥1 risk factor (mildRF+; n = 45), and moderate/severe TBI (n = 30). We measured set-shifting performance based on visual information (visual shift condition) and set-shifting performance based on audiovisual information, requiring multisensory integration (audiovisual shift condition). Effects of TBI on set-shifting performance were traced back to task strategy (i.e., boundary separation), processing efficiency (i.e., drift rate), or extradecisional processes (i.e., nondecision time) using diffusion model analysis. General neurocognitive functioning was measured using estimated full-scale IQ (FSIQ). Results: The TBI group showed selectively reduced performance in the audiovisual shift condition (p = .009, Cohen's d = -0.51). Follow-up analyses in the audiovisual shift condition revealed reduced performance in the mildRF+ TBI group and moderate/severe TBI group (ps ≤ .025, ds ≤ -0.61). These effects were traced back to lower drift rate (ps ≤ .048, ds ≤ -0.44), reflecting reduced multisensory integration efficiency. Notably, accuracy and drift rate in the audiovisual shift condition partially mediated the relation between TBI and FSIQ. Conclusion: Children with mildRF+ or moderate/severe TBI are at risk for reduced multisensory integration efficiency, possibly contributing to decreased general neurocognitive functioning.

AB - To investigate the impact of pediatric traumatic brain injury (TBI) on multisensory integration in relation to general neurocognitive functioning. Method: Children with a hospital admission for TBI aged between 6 and 13 years (n = 94) were compared with children with trauma control (TC) injuries (n = 39), while differentiating between mild TBI without risk factors for complicated TBI (mildRF-; n = 19), mild TBI with ≥1 risk factor (mildRF+; n = 45), and moderate/severe TBI (n = 30). We measured set-shifting performance based on visual information (visual shift condition) and set-shifting performance based on audiovisual information, requiring multisensory integration (audiovisual shift condition). Effects of TBI on set-shifting performance were traced back to task strategy (i.e., boundary separation), processing efficiency (i.e., drift rate), or extradecisional processes (i.e., nondecision time) using diffusion model analysis. General neurocognitive functioning was measured using estimated full-scale IQ (FSIQ). Results: The TBI group showed selectively reduced performance in the audiovisual shift condition (p = .009, Cohen's d = -0.51). Follow-up analyses in the audiovisual shift condition revealed reduced performance in the mildRF+ TBI group and moderate/severe TBI group (ps ≤ .025, ds ≤ -0.61). These effects were traced back to lower drift rate (ps ≤ .048, ds ≤ -0.44), reflecting reduced multisensory integration efficiency. Notably, accuracy and drift rate in the audiovisual shift condition partially mediated the relation between TBI and FSIQ. Conclusion: Children with mildRF+ or moderate/severe TBI are at risk for reduced multisensory integration efficiency, possibly contributing to decreased general neurocognitive functioning.

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Königs M, Weeda WD, van Heurn LWE, Vermeulen RJ, Goslings JC, Luitse JSK et al. Pediatric traumatic brain injury affects multisensory integration. Neuropsychology. 2017 Feb 1;31(2):137-148. https://doi.org/10.1037/neu0000302