Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis

Olivier A. Pluut, Carlotta Bianco, Ivone Jakasa, Maaike J. Visser, Petra Krystek, Francesca Larese-Filon, Thomas Rustemeyer, Sanja Kezic*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Human data on dermal absorption of silver under "in use" scenario are scarce which hampers health risk assessment. The main objective of the present study was to determine percutaneous penetration of silver after dermal exposure to silver containing garment in healthy individuals and atopic dermatitis (AD) patients. Next to assess pro-inflammatory effect of silver in the skin. Healthy subjects (n=15) and patients with AD (n=15) wore a sleeve containing 3.6% (w/w) silver on their lower arms for 8h during 5 consecutive days. The percutaneous penetration parameters were deduced from the silver concentration-depth profiles in the stratum corneum (SC) collected by adhesive tapes. Furthermore, silver was measured in urine samples collected before and after exposure. Inflammatory response was assessed by measuring IL-1α and IL-1RA in the exposed and non-exposed skin sites. Dermal flux of silver in healthy subjects and AD patients was respectively 0.23 and 0.20ng/cm2/h. The urine silver concentrations showed no increase after exposure. Furthermore, exposure to silver did not lead to the changes in the profiles of IL-1α and IL-1RA. Dermal absorption of silver under "real life scenario" was lower than the current reference dose. Furthermore, dermal exposure did not lead to altered expression of inflammatory IL-1 cytokines in the skin.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalToxicology Letters
Volume235
Issue number2
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Atopic dermatitis
  • Cytokines
  • Dermal exposure
  • Percutaneous penetration
  • Silver

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