Performance monitoring in obsessive-compulsive disorder

S.T. Nieuwenhuis, M. Nielen, N. Mol, G. Hajcak, D.J. Veltman

Research output: Contribution to JournalArticleAcademicpeer-review


Obsessive-compulsive disorder (OCD) is associated with hyperactivity of brain structures involved in performance monitoring. It has been proposed that this pathophysiology results in the generation of inappropriate or excessive internal error signals, giving rise to the characteristic symptoms of OCD. We measured an electrophysiological correlate of performance monitoring, error-related negativity (ERN), to study whether OCD patients exhibit enhanced brain activity associated with errors and negative performance feedback. We found that OCD patients (n=16) and healthy control participants (n=16) did not differ in the amplitude of the ERN associated with errors and negative feedback in a probabilistic learning task. The discrepancy between these results and the results from previous studies is discussed.
Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalPsychiatry Research
Issue number2
Early online date30 Mar 2005
Publication statusPublished - 15 Apr 2005


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