TY - JOUR
T1 - Personalization matters
T2 - the effect of sex in multivitamin-multimineral-based cancer prevention
AU - Šelb, Julij
AU - Cvetko, Filip
AU - Deutsch, Leon
AU - Bedrač, Leon
AU - Kuščer, Enej
AU - Maier, Andrea Britta
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/2
Y1 - 2024/2
N2 - The prevention of non-communicable diseases like cancer contributes to healthy aging. Dietary supplements might support such prevention; their effect likely depends on the personal characteristics of the individuals receiving them. To evaluate the influence of sex on reducing cancer incidence with multivitamin-multimineral (MVM) supplementation, sex-specific results of the efficacy of MVM supplementation for cancer prevention were collected and meta-analyzed (using fixed effect (FE) and random effect (RE) models). Three trials included in the “US Preventive Services Task Force Recommendation Statement Report regarding Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer” were used, namely, COSMOS, SU.VI.MAX, and PHS2. A total of 28,558 men and 20,542 women were included. Multivitamin-multimineral supplementation significantly reduced cancer incidence in the entire population (HR 0.93 [95% CI, 0.88–0.99], FE and RE); sex-specific meta-analysis showed beneficial effects of supplementation in men (HR 0.91 [95% CI, 0.85–0.97] (FE)/0.88 [95% CI, 0.77–1.01] (RE)); however, there was no effect in women (HR 1.00 [95% CI, 0.88–1.14], FR and RE); (P difference = 0.17). Sex could influence the effect of MVM supplementation in reducing cancer incidence, with supplementation being effective only in male individuals. These results might be informative for future research and public health policy makers.
AB - The prevention of non-communicable diseases like cancer contributes to healthy aging. Dietary supplements might support such prevention; their effect likely depends on the personal characteristics of the individuals receiving them. To evaluate the influence of sex on reducing cancer incidence with multivitamin-multimineral (MVM) supplementation, sex-specific results of the efficacy of MVM supplementation for cancer prevention were collected and meta-analyzed (using fixed effect (FE) and random effect (RE) models). Three trials included in the “US Preventive Services Task Force Recommendation Statement Report regarding Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer” were used, namely, COSMOS, SU.VI.MAX, and PHS2. A total of 28,558 men and 20,542 women were included. Multivitamin-multimineral supplementation significantly reduced cancer incidence in the entire population (HR 0.93 [95% CI, 0.88–0.99], FE and RE); sex-specific meta-analysis showed beneficial effects of supplementation in men (HR 0.91 [95% CI, 0.85–0.97] (FE)/0.88 [95% CI, 0.77–1.01] (RE)); however, there was no effect in women (HR 1.00 [95% CI, 0.88–1.14], FR and RE); (P difference = 0.17). Sex could influence the effect of MVM supplementation in reducing cancer incidence, with supplementation being effective only in male individuals. These results might be informative for future research and public health policy makers.
KW - Dietary supplements
KW - Meta-analysis
KW - Primary cancer prevention
KW - Sex/gender
KW - Vitamins/minerals
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U2 - 10.1007/s11357-023-00882-7
DO - 10.1007/s11357-023-00882-7
M3 - Article
C2 - 37561385
AN - SCOPUS:85167583025
SN - 2509-2715
VL - 46
SP - 1351
EP - 1356
JO - GeroScience
JF - GeroScience
IS - 1
ER -