Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration

N P Vermeulen, M W Teunissen, D D Breimer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half-live of 11.0 +/- 1.2 h (n=4). Peak levels were reached at 2.7 +/- 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/- 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/- 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half-lives were slightly shorter than the corresponding plasma half-lives.

Original languageEnglish
Pages (from-to)459-63
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume8
Issue number5
DOIs
Publication statusPublished - Nov 1979

Keywords

  • Administration, Oral
  • Adult
  • Humans
  • Male
  • Pemoline
  • Saliva
  • Time Factors
  • Journal Article

Fingerprint Dive into the research topics of 'Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration'. Together they form a unique fingerprint.

  • Cite this