Abstract
1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half-live of 11.0 +/- 1.2 h (n=4). Peak levels were reached at 2.7 +/- 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/- 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/- 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half-lives were slightly shorter than the corresponding plasma half-lives.
Original language | English |
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Pages (from-to) | 459-63 |
Number of pages | 5 |
Journal | British Journal of Clinical Pharmacology |
Volume | 8 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1979 |
Keywords
- Administration, Oral
- Adult
- Humans
- Male
- Pemoline
- Saliva
- Time Factors
- Journal Article