Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories

L. Diergaarde, A.N.M. Schoffelmeer, T.J. de Vries

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Well-consolidated memories, when retrieved, may return to a transiently fragile state, and need to be consolidated again in order to be maintained. This process has been referred to as memory reconsolidation and presumably serves to modify or strengthen memory traces. In recent years, our understanding of the neurobiological mechanisms underlying this phenomenon has increased rapidly. Here, we will briefly review some of the pharmacological evidence, stressing a crucial role for the brain's major neurotransmitter systems, such as glutamate and noradrenaline, in memory reconsolidation. Pharmacological intervention of reconsolidation processes may have clinical relevance, especially for the treatment of psychiatric disorders that are characterized by pathological memories, including post-traumatic stress disorder and addictive behaviour. © 2008 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)453-457
    JournalEuropean Journal of Pharmacology
    Volume585
    Issue number2-3
    DOIs
    Publication statusPublished - 2008

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