TY - JOUR
T1 - Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories
AU - Diergaarde, L.
AU - Schoffelmeer, A.N.M.
AU - de Vries, T.J.
PY - 2008
Y1 - 2008
N2 - Well-consolidated memories, when retrieved, may return to a transiently fragile state, and need to be consolidated again in order to be maintained. This process has been referred to as memory reconsolidation and presumably serves to modify or strengthen memory traces. In recent years, our understanding of the neurobiological mechanisms underlying this phenomenon has increased rapidly. Here, we will briefly review some of the pharmacological evidence, stressing a crucial role for the brain's major neurotransmitter systems, such as glutamate and noradrenaline, in memory reconsolidation. Pharmacological intervention of reconsolidation processes may have clinical relevance, especially for the treatment of psychiatric disorders that are characterized by pathological memories, including post-traumatic stress disorder and addictive behaviour. © 2008 Elsevier B.V. All rights reserved.
AB - Well-consolidated memories, when retrieved, may return to a transiently fragile state, and need to be consolidated again in order to be maintained. This process has been referred to as memory reconsolidation and presumably serves to modify or strengthen memory traces. In recent years, our understanding of the neurobiological mechanisms underlying this phenomenon has increased rapidly. Here, we will briefly review some of the pharmacological evidence, stressing a crucial role for the brain's major neurotransmitter systems, such as glutamate and noradrenaline, in memory reconsolidation. Pharmacological intervention of reconsolidation processes may have clinical relevance, especially for the treatment of psychiatric disorders that are characterized by pathological memories, including post-traumatic stress disorder and addictive behaviour. © 2008 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.ejphar.2008.03.010
DO - 10.1016/j.ejphar.2008.03.010
M3 - Article
SN - 0014-2999
VL - 585
SP - 453
EP - 457
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -