Phosphatidic acid mediates demyelination in Lpin1 mutant mice

K. Nadra, C.A.S. De Preux, J.J. Medard, W.T.J. Hendriks, G.S. Han, S. Gres, G.M. Carman, J.S. Saulnier-Blache, M.H.G. Verheijen, R. Chrast

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg
Original languageEnglish
Pages (from-to)1647-1661
JournalGenes and Development
Volume22
DOIs
Publication statusPublished - 2008

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    Nadra, K., De Preux, C. A. S., Medard, J. J., Hendriks, W. T. J., Han, G. S., Gres, S., ... Chrast, R. (2008). Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes and Development, 22, 1647-1661. https://doi.org/10.1101/gad.1638008