Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins

J M Boer, J.A. Kuivenhoven, E.J. Feskens, E G Schouten, L.M. Havekes, J C Seidell, J.J. Kastelein, D. Kromhout

Research output: Contribution to JournalArticleAcademicpeer-review


We investigated interactions between a mutation (D9N) in the lipoprotein lipase (LPL) gene and physical activity, as well as other lifestyle factors, on lipid traits in a population-based sample of Dutch men and women (n = 379). We used questionnaire information to classify physical activity, alcohol consumption, and smoking habits, while overweight was defined as a body mass index (BMI) > 25 kg/m2. Non-fasting blood samples were used for the determination of lipid traits and the D9N genotype. Fifteen subjects (4%) carried the mutation. They presented with higher levels of total cholesterol, apolipoprotein (apo) B and triglycerides compared to non-carriers. While no interactions with overweight, alcohol consumption, and smoking were found, a strong interaction between the D9N mutation and physical activity became apparent. Physically inactive D9N carriers (n = 5) had considerably higher total cholesterol (+2 mmol/l, p < or = 0.0001) and apo B levels (+63 mg/dl, p < or = 0.0001) compared to non-carriers of this mutation, whereas their high-density lipoprotein (HDL)-cholesterol concentrations were lower (-0.22 mmol/l, p < 0.05). This was not the case for physically active D9N carriers (n = 10). In conclusion, a common variant of the LPL gene (D9N) adversely affects plasma lipid and lipoprotein profiles. However, the unfavorable consequences may be counteracted by physical activity.

Original languageEnglish
Pages (from-to)158-63
Number of pages6
JournalClinical Genetics
Issue number2
Publication statusPublished - Aug 1999


  • Adult
  • Alcohol Drinking
  • Body Mass Index
  • Cholesterol, HDL
  • Exercise
  • Female
  • Heterozygote
  • Humans
  • Lipids
  • Lipoprotein Lipase
  • Male
  • Middle Aged
  • Mutation
  • Netherlands
  • Random Allocation
  • Smoking
  • Journal Article
  • Research Support, Non-U.S. Gov't


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