Physical virology: how physics is enabling a better understanding of recent viral invaders

Ruana Cardoso-Lima; Ralph Santos-Oliveira; Pedro Filho Noronha Souza; Leandro R.S. Barbosa; Gijs J.L. Wuite; Luciana Magalhães Rebelo Alencar

doi:10.1007/s12551-023-01075-4

Physical virology: how physics is enabling a better understanding of recent viral invaders

Ruana Cardoso-Lima, Ralph Santos-Oliveira, Pedro Filho Noronha Souza, Leandro R.S. Barbosa, Gijs J.L. Wuite, Luciana Magalhães Rebelo Alencar^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies’ fundamental components work to counteract them. Determining the ultrastructure and nanomechanical characteristics of viruses from a physical standpoint helps categorize their mechanical characteristics, offers insight into new treatment options, and/or shows weak spots that can clarify methods for medication targeting. This study compiles the findings from studies on the ultrastructure and nanomechanical behavior of SARS-CoV-2, ZIKV (Zika virus), and CHIKV (Chikungunya virus) viral particles. With results that uncovered aspects of the organization and the spatial distribution of the proteins on the surface of the viral particle as well as the deformation response of the particles when applied a recurring loading force, this review aims to provide further discussion on the mechanical properties of viral particles at the nanoscale, offering new prospects that could be employed for designing strategies for the prevention and treatment of viral diseases.

Original language	English
Pages (from-to)	611-623
Number of pages	13
Journal	Biophysical Reviews
Volume	15
Issue number	4
Early online date	17 Jun 2023
DOIs	https://doi.org/10.1007/s12551-023-01075-4
Publication status	Published - Aug 2023

Bibliographical note

Funding Information:
This study was funded by CAPES Financial Code 001, FAPEMA, Projeto UNIVERSAL-06929/22, Bolsa de Produtividade CNPq, Luciana Magalhães Rebelo Alencar - 304774/2021-9, FAPESP (2017/26131-5) Leandro thanks CNPq for research funding (309418/2021-6).

Publisher Copyright:
© 2023, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.

Funding

This study was funded by CAPES Financial Code 001, FAPEMA, Projeto UNIVERSAL-06929/22, Bolsa de Produtividade CNPq, Luciana Magalhães Rebelo Alencar - 304774/2021-9, FAPESP (2017/26131-5) Leandro thanks CNPq for research funding (309418/2021-6).

Funders	Funder number
Luciana Magalhães Rebelo Alencar	304774/2021-9
Fundação de Amparo à Pesquisa do Estado de São Paulo	309418/2021-6, 2017/26131-5
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão	UNIVERSAL-06929/22

Keywords

AFM
Chikungunya
Nanomechanics
Physical virology
SARS-CoV-2
Zika

Access to Document

10.1007/s12551-023-01075-4

Physical virology_how physics is enabling a better understanding of recent viral invadersFinal published version, 1.36 MBLicence: Article 25fa Dutch Copyright Act

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Cite this

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abstract = "The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies{\textquoteright} fundamental components work to counteract them. Determining the ultrastructure and nanomechanical characteristics of viruses from a physical standpoint helps categorize their mechanical characteristics, offers insight into new treatment options, and/or shows weak spots that can clarify methods for medication targeting. This study compiles the findings from studies on the ultrastructure and nanomechanical behavior of SARS-CoV-2, ZIKV (Zika virus), and CHIKV (Chikungunya virus) viral particles. With results that uncovered aspects of the organization and the spatial distribution of the proteins on the surface of the viral particle as well as the deformation response of the particles when applied a recurring loading force, this review aims to provide further discussion on the mechanical properties of viral particles at the nanoscale, offering new prospects that could be employed for designing strategies for the prevention and treatment of viral diseases.",

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Physical virology: how physics is enabling a better understanding of recent viral invaders

Abstract

Bibliographical note

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Keywords

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