Physics of viral dynamics

Robijn F. Bruinsma; Gijs J.L. Wuite; Wouter H. Roos

doi:10.1038/s42254-020-00267-1

Physics of viral dynamics

Robijn F. Bruinsma
, Gijs J.L. Wuite
, Wouter H. Roos^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

158 Downloads (Pure)

Abstract

Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics.

Original language	English
Pages (from-to)	76-91
Number of pages	16
Journal	Nature Reviews Physics
Volume	3
Issue number	2
Early online date	12 Jan 2021
DOIs	https://doi.org/10.1038/s42254-020-00267-1
Publication status	Published - Feb 2021

Funding

The authors thank C. Knobler for a critical reading of the manuscript, and C. Uetrecht and S. Maity for their input. W.H.R. is supported by a VIDI grant from the Nederlandse Oganizatie voor Wetenschappelijk Onderzoek. R.B. is supported by the NSF-DMR under CMMT grant 1836404.

Funders	Funder number
NSF-DMR
Nederlandse Oganizatie voor Wetenschappelijk Onderzoek
CMMT
National Science Foundation	1836404
UK Research and Innovation	104115

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 12 Responsible Consumption and Production

Access to Document

10.1038/s42254-020-00267-1

Physics of viral dynamicsFinal published version, 3.13 MBLicence: Article 25fa Dutch Copyright Act

Persistent URL (handle)

Persistent link

Cite this

@article{9e62dad68e9d4a28bd0f8f36cead0fa5,

title = "Physics of viral dynamics",

abstract = "Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics.",

author = "Bruinsma, \{Robijn F.\} and Wuite, \{Gijs J.L.\} and Roos, \{Wouter H.\}",

year = "2021",

month = feb,

doi = "10.1038/s42254-020-00267-1",

language = "English",

volume = "3",

pages = "76--91",

journal = "Nature Reviews Physics",

issn = "2522-5820",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - Physics of viral dynamics

AU - Bruinsma, Robijn F.

AU - Wuite, Gijs J.L.

AU - Roos, Wouter H.

PY - 2021/2

Y1 - 2021/2

N2 - Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics.

AB - Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics.

UR - https://www.scopus.com/pages/publications/85100040536

UR - https://www.scopus.com/pages/publications/85100040536#tab=citedBy

U2 - 10.1038/s42254-020-00267-1

DO - 10.1038/s42254-020-00267-1

M3 - Review article

AN - SCOPUS:85100040536

SN - 2522-5820

VL - 3

SP - 76

EP - 91

JO - Nature Reviews Physics

JF - Nature Reviews Physics

IS - 2

ER -

Physics of viral dynamics

Abstract

Funding

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this