Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study

Jamie S McPhee, Jean-Yves Hogrel, Andrea B Maier, Enn Seppet, Olivier R Seynnes, Sarianna Sipilä, Roberto Bottinelli, Yoann Barnouin, Astrid Y Bijlsma, Helena Gapeyeva, Thomas M Maden-Wilkinson, Carel G Meskers, Mati Pääsuke, Elina Sillanpää, Lauri Stenroth, Gillian Butler-Browne, Marco V Narici, David A Jones

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions in mobility in older age. The methodology has been described here. Test centres were located in Manchester, UK; Paris, France; Leiden, The Netherlands; Tartu, Estonia and Jyväskylä, Finland. In total, 182 young (18-30 years old, 52.2 % female) and 322 older adults (69-81 years old, 50 % female) have been examined. The participants were independent living, socially active and free from disease that impaired mobility levels. The older participants were selected based on physical activity levels, such that half exceeded current recommended physical activity levels and the other half had lower physical activity levels than is recommended to maintain health. Measurements consisted of blood pressure; anthropometry and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging); lung function; standing balance and cognitive function (CANTAB). Mobility was assessed using the Timed Up and Go, a 6 min walk, activity questionnaires and accelerometers to monitor habitual daily activities. Muscle strength, power, fatigue and neural activation were assessed using a combination of voluntary and electrically stimulated contractions. Fasting blood samples and skeletal muscle biopsies were collected for detailed examination of cell and molecular differences between young and older individuals. The results from this study will provide a detailed insight into "normal, healthy" ageing, linking whole-body function to the structure and function of the neuromuscular system and the molecular characteristics of skeletal muscle.

Original languageEnglish
Pages (from-to)325-37
Number of pages13
JournalBiogerontology
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2013

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Exercise
Skeletal Muscle
Estonia
Independent Living
Anthropometry
Photon Absorptiometry
Muscle Strength
Paris
Finland
Body Composition
Netherlands
Cognition
France
Fatigue
Fasting
Magnetic Resonance Imaging
Blood Pressure
Biopsy
Muscles
Lung

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Blood Pressure/physiology
  • Body Composition/physiology
  • Europe
  • Exercise Test
  • Female
  • Health Status
  • Heart Rate/physiology
  • Humans
  • Male
  • Motor Activity/physiology
  • Muscle Strength/physiology
  • Muscle, Skeletal/physiology
  • Neuropsychological Tests
  • Respiratory Function Tests
  • Walking/physiology
  • Young Adult

Cite this

McPhee, Jamie S ; Hogrel, Jean-Yves ; Maier, Andrea B ; Seppet, Enn ; Seynnes, Olivier R ; Sipilä, Sarianna ; Bottinelli, Roberto ; Barnouin, Yoann ; Bijlsma, Astrid Y ; Gapeyeva, Helena ; Maden-Wilkinson, Thomas M ; Meskers, Carel G ; Pääsuke, Mati ; Sillanpää, Elina ; Stenroth, Lauri ; Butler-Browne, Gillian ; Narici, Marco V ; Jones, David A. / Physiological and functional evaluation of healthy young and older men and women : design of the European MyoAge study. In: Biogerontology. 2013 ; Vol. 14, No. 3. pp. 325-37.
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McPhee, JS, Hogrel, J-Y, Maier, AB, Seppet, E, Seynnes, OR, Sipilä, S, Bottinelli, R, Barnouin, Y, Bijlsma, AY, Gapeyeva, H, Maden-Wilkinson, TM, Meskers, CG, Pääsuke, M, Sillanpää, E, Stenroth, L, Butler-Browne, G, Narici, MV & Jones, DA 2013, 'Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study' Biogerontology, vol. 14, no. 3, pp. 325-37. https://doi.org/10.1007/s10522-013-9434-7

Physiological and functional evaluation of healthy young and older men and women : design of the European MyoAge study. / McPhee, Jamie S; Hogrel, Jean-Yves; Maier, Andrea B; Seppet, Enn; Seynnes, Olivier R; Sipilä, Sarianna; Bottinelli, Roberto; Barnouin, Yoann; Bijlsma, Astrid Y; Gapeyeva, Helena; Maden-Wilkinson, Thomas M; Meskers, Carel G; Pääsuke, Mati; Sillanpää, Elina; Stenroth, Lauri; Butler-Browne, Gillian; Narici, Marco V; Jones, David A.

In: Biogerontology, Vol. 14, No. 3, 06.2013, p. 325-37.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Physiological and functional evaluation of healthy young and older men and women

T2 - design of the European MyoAge study

AU - McPhee, Jamie S

AU - Hogrel, Jean-Yves

AU - Maier, Andrea B

AU - Seppet, Enn

AU - Seynnes, Olivier R

AU - Sipilä, Sarianna

AU - Bottinelli, Roberto

AU - Barnouin, Yoann

AU - Bijlsma, Astrid Y

AU - Gapeyeva, Helena

AU - Maden-Wilkinson, Thomas M

AU - Meskers, Carel G

AU - Pääsuke, Mati

AU - Sillanpää, Elina

AU - Stenroth, Lauri

AU - Butler-Browne, Gillian

AU - Narici, Marco V

AU - Jones, David A

PY - 2013/6

Y1 - 2013/6

N2 - Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions in mobility in older age. The methodology has been described here. Test centres were located in Manchester, UK; Paris, France; Leiden, The Netherlands; Tartu, Estonia and Jyväskylä, Finland. In total, 182 young (18-30 years old, 52.2 % female) and 322 older adults (69-81 years old, 50 % female) have been examined. The participants were independent living, socially active and free from disease that impaired mobility levels. The older participants were selected based on physical activity levels, such that half exceeded current recommended physical activity levels and the other half had lower physical activity levels than is recommended to maintain health. Measurements consisted of blood pressure; anthropometry and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging); lung function; standing balance and cognitive function (CANTAB). Mobility was assessed using the Timed Up and Go, a 6 min walk, activity questionnaires and accelerometers to monitor habitual daily activities. Muscle strength, power, fatigue and neural activation were assessed using a combination of voluntary and electrically stimulated contractions. Fasting blood samples and skeletal muscle biopsies were collected for detailed examination of cell and molecular differences between young and older individuals. The results from this study will provide a detailed insight into "normal, healthy" ageing, linking whole-body function to the structure and function of the neuromuscular system and the molecular characteristics of skeletal muscle.

AB - Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions in mobility in older age. The methodology has been described here. Test centres were located in Manchester, UK; Paris, France; Leiden, The Netherlands; Tartu, Estonia and Jyväskylä, Finland. In total, 182 young (18-30 years old, 52.2 % female) and 322 older adults (69-81 years old, 50 % female) have been examined. The participants were independent living, socially active and free from disease that impaired mobility levels. The older participants were selected based on physical activity levels, such that half exceeded current recommended physical activity levels and the other half had lower physical activity levels than is recommended to maintain health. Measurements consisted of blood pressure; anthropometry and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging); lung function; standing balance and cognitive function (CANTAB). Mobility was assessed using the Timed Up and Go, a 6 min walk, activity questionnaires and accelerometers to monitor habitual daily activities. Muscle strength, power, fatigue and neural activation were assessed using a combination of voluntary and electrically stimulated contractions. Fasting blood samples and skeletal muscle biopsies were collected for detailed examination of cell and molecular differences between young and older individuals. The results from this study will provide a detailed insight into "normal, healthy" ageing, linking whole-body function to the structure and function of the neuromuscular system and the molecular characteristics of skeletal muscle.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Blood Pressure/physiology

KW - Body Composition/physiology

KW - Europe

KW - Exercise Test

KW - Female

KW - Health Status

KW - Heart Rate/physiology

KW - Humans

KW - Male

KW - Motor Activity/physiology

KW - Muscle Strength/physiology

KW - Muscle, Skeletal/physiology

KW - Neuropsychological Tests

KW - Respiratory Function Tests

KW - Walking/physiology

KW - Young Adult

U2 - 10.1007/s10522-013-9434-7

DO - 10.1007/s10522-013-9434-7

M3 - Article

VL - 14

SP - 325

EP - 337

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

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ER -