Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management

M. Meleti, P. Vescovi, W.J. Mooi, I. van der Waal

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    Abstract

    The term "pigmentation of the oral mucosa" is applied to a wide range of lesions or conditions featuring a change of color of oral tissues. Lesions not associated with an accumulation of pigment (e.g., Fordyce spots) are usually not classified as pigmented lesions. Two groups of pigmented lesions of the oral mucosa are recognized: 1) melanin-associated lesions, including racial pigmentations, melanotic macules, melanocytic nevi, and malignant melanoma; and 2) nonmelanin-associated lesions (e.g., blood-related pigmentations, metallic pigmentations). This paper presents a clinicopathologic review of the recent literature with emphasis on the main diagnostic features, including the use of immunohistochemical markers. A flow-chart is added that may help the clinician in the diagnosis and management of these lesions.
    Original languageUndefined/Unknown
    Pages (from-to)606-616
    JournalOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
    Volume105
    Issue number5
    DOIs
    Publication statusPublished - 2008

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