TY - JOUR
T1 - Pitfalls and practical suggestions for using local field potential recordings in DBS clinical practice and research
AU - Swinnen, Bart E K S
AU - Buijink, Arthur W G
AU - Stam, Mariëlle J
AU - Hubers, Deborah
AU - de Neeling, Martijn
AU - Keulen, Bart J
AU - Morgante, Francesca
AU - van Wijk, Bernadette C M
AU - de Bie, Rob M A
AU - Ricciardi, Lucia
AU - Little, Simon J
AU - Beudel, Martijn
PY - 2025/2/1
Y1 - 2025/2/1
N2 - Objective. Local field potential (LFP) recordings using chronically implanted sensing-enabled stimulators are a powerful tool for indexing symptom presence and severity in neurological and neuropsychiatric disorders, and for enhancing our neurophysiological understanding of brain processes. LFPs have gained interest as input signals for closed-loop deep brain stimulation (DBS) and can be used to inform DBS parameter selection. LFP recordings using chronically implanted sensing-enabled stimulators have various implementational challenges. Approach. Here we describe our collective experience using BrainSense (Medtronic®) for clinical and research work. We aim to provide insightful tips and practical advice to empower readers with the knowledge needed to navigate the intricacies of the device and make the most out of its features. Main results. The central issues that apply to several BrainSense features encompass restricted compatibility of stimulation configuration with sensing, differences in electrophysiological signal properties between ‘stimulation OFF’ and ‘stimulation ON at 0.0 mA’, and challenges associated with the internal clock of the neurostimulator. In addition, since recordings are obtained from bipolar and not monopolar channels, spatial certainty regarding the distribution of LFPs around the DBS electrode is limited. Several options exist to synchronize LFP time series with external data streams, but standardization and generalization are lacking. The use of at-home chronic LFP recording is limited by a low temporal and spectral resolution. Regarding at-home LFP snapshots, LFP time series are not stored, parts of the power spectrum are censored when stimulating at high or low frequencies, and the stimulation amplitude is not readily available. Significance. We discussed practical applications, implementation, system limitations, and pitfalls with the aim that sensing can be better applied for clinical practice and research.
AB - Objective. Local field potential (LFP) recordings using chronically implanted sensing-enabled stimulators are a powerful tool for indexing symptom presence and severity in neurological and neuropsychiatric disorders, and for enhancing our neurophysiological understanding of brain processes. LFPs have gained interest as input signals for closed-loop deep brain stimulation (DBS) and can be used to inform DBS parameter selection. LFP recordings using chronically implanted sensing-enabled stimulators have various implementational challenges. Approach. Here we describe our collective experience using BrainSense (Medtronic®) for clinical and research work. We aim to provide insightful tips and practical advice to empower readers with the knowledge needed to navigate the intricacies of the device and make the most out of its features. Main results. The central issues that apply to several BrainSense features encompass restricted compatibility of stimulation configuration with sensing, differences in electrophysiological signal properties between ‘stimulation OFF’ and ‘stimulation ON at 0.0 mA’, and challenges associated with the internal clock of the neurostimulator. In addition, since recordings are obtained from bipolar and not monopolar channels, spatial certainty regarding the distribution of LFPs around the DBS electrode is limited. Several options exist to synchronize LFP time series with external data streams, but standardization and generalization are lacking. The use of at-home chronic LFP recording is limited by a low temporal and spectral resolution. Regarding at-home LFP snapshots, LFP time series are not stored, parts of the power spectrum are censored when stimulating at high or low frequencies, and the stimulation amplitude is not readily available. Significance. We discussed practical applications, implementation, system limitations, and pitfalls with the aim that sensing can be better applied for clinical practice and research.
UR - http://dx.doi.org/10.1088/1741-2552/adaeee
U2 - 10.1088/1741-2552/adaeee
DO - 10.1088/1741-2552/adaeee
M3 - Article
SN - 1741-2560
VL - 22
JO - Journal of Neural Engineering
JF - Journal of Neural Engineering
IS - 1
M1 - 014001
ER -