Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study

A. Becker; R.M.A. Henry; P.J. Kostense; C. Jakobs; T. Teerlink; S. Zweegman; J.M. Dekker; G. Nijpels; R.J. Heine; L.M. Bouter; Y.M. Smulders; C.D.A. Stehouwer

doi:10.1016/S0021-9150(03)00199-0

Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study

A. Becker, R.M.A. Henry, P.J. Kostense, C. Jakobs, T. Teerlink, S. Zweegman, J.M. Dekker, G. Nijpels, R.J. Heine, L.M. Bouter, Y.M. Smulders, C.D.A. Stehouwer

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Abstract

Objective: Hyperhomocysteinemia is a risk factor for atherothrombosis. Through unknown mechanisms, individuals with type 2 diabetes appear particularly susceptible. We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes. Methods and results: In a cross-sectional design, we studied 231 Caucasian individuals, 60.6% having type 2 diabetes. We measured fasting homocysteine, vitamin B

Original language	English
Pages (from-to)	323-330
Journal	Atherosclerosis
Volume	169
Issue number	2
DOIs	https://doi.org/10.1016/S0021-9150(03)00199-0
Publication status	Published - 2003

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Becker, A., Henry, R. M. A., Kostense, P. J., Jakobs, C., Teerlink, T., Zweegman, S., Dekker, J. M., Nijpels, G., Heine, R. J., Bouter, L. M., Smulders, Y. M., & Stehouwer, C. D. A. (2003). Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study. Atherosclerosis, 169(2), 323-330. https://doi.org/10.1016/S0021-9150(03)00199-0

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title = "Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study",

abstract = "Objective: Hyperhomocysteinemia is a risk factor for atherothrombosis. Through unknown mechanisms, individuals with type 2 diabetes appear particularly susceptible. We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes. Methods and results: In a cross-sectional design, we studied 231 Caucasian individuals, 60.6\% having type 2 diabetes. We measured fasting homocysteine, vitamin B",

author = "A. Becker and R.M.A. Henry and P.J. Kostense and C. Jakobs and T. Teerlink and S. Zweegman and J.M. Dekker and G. Nijpels and R.J. Heine and L.M. Bouter and Y.M. Smulders and C.D.A. Stehouwer",

year = "2003",

doi = "10.1016/S0021-9150(03)00199-0",

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Becker, A, Henry, RMA, Kostense, PJ, Jakobs, C, Teerlink, T, Zweegman, S, Dekker, JM, Nijpels, G, Heine, RJ, Bouter, LM, Smulders, YM & Stehouwer, CDA 2003, 'Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study', Atherosclerosis, vol. 169, no. 2, pp. 323-330. https://doi.org/10.1016/S0021-9150(03)00199-0

Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study. / Becker, A.; Henry, R.M.A.; Kostense, P.J. et al.
In: Atherosclerosis, Vol. 169, No. 2, 2003, p. 323-330.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study

AU - Becker, A.

AU - Henry, R.M.A.

AU - Kostense, P.J.

AU - Jakobs, C.

AU - Teerlink, T.

AU - Zweegman, S.

AU - Dekker, J.M.

AU - Nijpels, G.

AU - Heine, R.J.

AU - Bouter, L.M.

AU - Smulders, Y.M.

AU - Stehouwer, C.D.A.

PY - 2003

Y1 - 2003

N2 - Objective: Hyperhomocysteinemia is a risk factor for atherothrombosis. Through unknown mechanisms, individuals with type 2 diabetes appear particularly susceptible. We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes. Methods and results: In a cross-sectional design, we studied 231 Caucasian individuals, 60.6% having type 2 diabetes. We measured fasting homocysteine, vitamin B

AB - Objective: Hyperhomocysteinemia is a risk factor for atherothrombosis. Through unknown mechanisms, individuals with type 2 diabetes appear particularly susceptible. We determined whether components of homocysteine metabolism are associated with intima-media thickness in individuals with and without type 2 diabetes. Methods and results: In a cross-sectional design, we studied 231 Caucasian individuals, 60.6% having type 2 diabetes. We measured fasting homocysteine, vitamin B

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U2 - 10.1016/S0021-9150(03)00199-0

DO - 10.1016/S0021-9150(03)00199-0

M3 - Article

SN - 0021-9150

VL - 169

SP - 323

EP - 330

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Plasma homocysteine and S-adenosylmethionine in erythrocytes as determinants of carotid intima-media thickness: different effects in diabetic and non-diabetic individuals The Hoorn Study

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