TY - JOUR
T1 - Plasma Parathyroid Hormone Is Independently Related to Nocturnal Blood Pressure in Hypertensive Patients
T2 - The Styrian Hypertension Study
AU - Verheyen, Nicolas D
AU - Kienreich, Katharina
AU - Gaksch, Martin
AU - van Ballegooijen, Adriana J
AU - Grübler, Martin R
AU - Hartaigh, Briain Ó
AU - Schmid, Johannes
AU - Fahrleitner-Pammer, Astrid
AU - Kraigher-Krainer, Elisabeth
AU - Colantonio, Caterina
AU - Belyavskiy, Evgeny
AU - Treiber, Gerlies
AU - Catena, Cristiana
AU - Brussee, Helmut
AU - Pieske, Burkert
AU - März, Winfried
AU - Tomaschitz, Andreas
AU - Pilz, Stefan
N1 - ©2015 Wiley Periodicals, Inc.
PY - 2016/6
Y1 - 2016/6
N2 - High parathyroid hormone (PTH) has been linked with high blood pressure (BP), but the relationship with 24-hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross-sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (mean age, 61±11 years; 53% women). Median plasma PTH (interquartile range) determined after an overnight fast was 49 pg/mL (39-61), mean daytime BP was 131/80±12/9 mm Hg, and mean nocturnal BP was 115/67±14/9 mm Hg. In multivariate regression analyses adjusted for BP and PTH-modifying parameters, PTH was significantly related to nocturnal systolic and diastolic BP (adjusted β-coefficient 0.140 [P=.03] and 0.175 [P<.01], respectively). PTH was not correlated with daytime BP readings. These data suggest a direct interrelationship between PTH and nocturnal BP regulation. Whether lowering high PTH concentrations reduces the burden of high nocturnal BP remains to be shown in future studies.
AB - High parathyroid hormone (PTH) has been linked with high blood pressure (BP), but the relationship with 24-hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross-sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (mean age, 61±11 years; 53% women). Median plasma PTH (interquartile range) determined after an overnight fast was 49 pg/mL (39-61), mean daytime BP was 131/80±12/9 mm Hg, and mean nocturnal BP was 115/67±14/9 mm Hg. In multivariate regression analyses adjusted for BP and PTH-modifying parameters, PTH was significantly related to nocturnal systolic and diastolic BP (adjusted β-coefficient 0.140 [P=.03] and 0.175 [P<.01], respectively). PTH was not correlated with daytime BP readings. These data suggest a direct interrelationship between PTH and nocturnal BP regulation. Whether lowering high PTH concentrations reduces the burden of high nocturnal BP remains to be shown in future studies.
KW - Journal Article
U2 - 10.1111/jch.12710
DO - 10.1111/jch.12710
M3 - Article
C2 - 26456544
SN - 1524-6175
VL - 18
SP - 543
EP - 550
JO - Journal of clinical hypertension
JF - Journal of clinical hypertension
IS - 6
ER -
