Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex

Alessio Fracasso; Serge O. Dumoulin; Natalia Petridou

doi:10.1016/j.pneurobio.2021.102187

Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex

Alessio Fracasso^*, Serge O. Dumoulin, Natalia Petridou

^*Corresponding author for this work

Cognitive Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

109 Downloads (Pure)

Abstract

Columns and layers are fundamental organizational units of the brain. Well known examples of cortical columns are the ocular dominance columns (ODCs) in primary visual cortex and the column-like stripe-based arrangement in the second visual area V2. The spatial scale of columns and layers is beyond the reach of conventional neuroimaging, but the advent of high field magnetic resonance imaging (MRI) scanners (UHF, 7 Tesla and above) has opened the possibility to acquire data at this spatial scale, in-vivo and non-invasively in humans. The most prominent non-invasive technique to measure brain function is blood oxygen level dependent (BOLD) fMRI, measuring brain activity indirectly, via changes in hemodynamics. A key determinant of the ability of high-resolution BOLD fMRI to accurately resolve columns and layers is the point-spread function (PSF) of the BOLD response in relation to the spatial extent of neuronal activity. In this study we take advantage of the stripe-based arrangement present in visual area V2, coupled with sub-millimetre anatomical and gradient-echo BOLD (GE BOLD) acquisition at 7 T to obtain PSF estimates and along cortical depth in human participants. Results show that the BOLD PSF is maximal in the superficial part of the cortex (1.78 mm), and it decreases with increasing cortical depth (0.83 mm close to white matter).

Original language	English
Article number	102187
Pages (from-to)	1-11
Number of pages	11
Journal	Progress in Neurobiology
Volume	207
Early online date	16 Nov 2021
DOIs	https://doi.org/10.1016/j.pneurobio.2021.102187
Publication status	Published - Dec 2021

Bibliographical note

This article is a reprint of a previously published article. For citation purposes, please use the original publication details; Progress in Neurobiology, Volume 202, July 2021, 102034

Funding Information:
This work was supported by the Netherlands Organization for Scientific Research (NWO) , Vidi Grant number 13339 (N.P.), Vici Grant number 016.Vici.185.050 (S.O.D.), the National Institute of Mental Health of the National Institutes of Health under award number R01MH111417 (N.P.). A.F. is supported by a grant from the Biotechnology and Biology research council (BBSRC, grant number: BB/S006605/1 ) and the Bial Foundation , Bial Foundation Grants Programme 2020/21, A-29315 .

Publisher Copyright:
© 2021

Funding

This work was supported by the Netherlands Organization for Scientific Research (NWO) , Vidi Grant number 13339 (N.P.), Vici Grant number 016.Vici.185.050 (S.O.D.), the National Institute of Mental Health of the National Institutes of Health under award number R01MH111417 (N.P.). A.F. is supported by a grant from the Biotechnology and Biology research council (BBSRC, grant number: BB/S006605/1 ) and the Bial Foundation , Bial Foundation Grants Programme 2020/21, A-29315 .

Keywords

7Tesla
BOLD
Cortical depth
Point-spread function

Access to Document

10.1016/j.pneurobio.2021.102187

Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortexFinal published version, 5.7 MBLicence: Article 25fa Dutch Copyright Act

Persistent URL (handle)

Persistent link

Cite this

@article{d2788f5de7fe40c28dcc22dfec696216,

title = "Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex",

abstract = "Columns and layers are fundamental organizational units of the brain. Well known examples of cortical columns are the ocular dominance columns (ODCs) in primary visual cortex and the column-like stripe-based arrangement in the second visual area V2. The spatial scale of columns and layers is beyond the reach of conventional neuroimaging, but the advent of high field magnetic resonance imaging (MRI) scanners (UHF, 7 Tesla and above) has opened the possibility to acquire data at this spatial scale, in-vivo and non-invasively in humans. The most prominent non-invasive technique to measure brain function is blood oxygen level dependent (BOLD) fMRI, measuring brain activity indirectly, via changes in hemodynamics. A key determinant of the ability of high-resolution BOLD fMRI to accurately resolve columns and layers is the point-spread function (PSF) of the BOLD response in relation to the spatial extent of neuronal activity. In this study we take advantage of the stripe-based arrangement present in visual area V2, coupled with sub-millimetre anatomical and gradient-echo BOLD (GE BOLD) acquisition at 7 T to obtain PSF estimates and along cortical depth in human participants. Results show that the BOLD PSF is maximal in the superficial part of the cortex (1.78 mm), and it decreases with increasing cortical depth (0.83 mm close to white matter).",

keywords = "7Tesla, BOLD, Cortical depth, Point-spread function",

author = "Alessio Fracasso and Dumoulin, \{Serge O.\} and Natalia Petridou",

note = "This article is a reprint of a previously published article. For citation purposes, please use the original publication details; Progress in Neurobiology, Volume 202, July 2021, 102034 Funding Information: This work was supported by the Netherlands Organization for Scientific Research (NWO) , Vidi Grant number 13339 (N.P.), Vici Grant number 016.Vici.185.050 (S.O.D.), the National Institute of Mental Health of the National Institutes of Health under award number R01MH111417 (N.P.). A.F. is supported by a grant from the Biotechnology and Biology research council (BBSRC, grant number: BB/S006605/1 ) and the Bial Foundation , Bial Foundation Grants Programme 2020/21, A-29315 . Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = dec,

doi = "10.1016/j.pneurobio.2021.102187",

language = "English",

volume = "207",

pages = "1--11",

journal = "Progress in Neurobiology",

issn = "0301-0082",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex

AU - Fracasso, Alessio

AU - Dumoulin, Serge O.

AU - Petridou, Natalia

N1 - This article is a reprint of a previously published article. For citation purposes, please use the original publication details; Progress in Neurobiology, Volume 202, July 2021, 102034 Funding Information: This work was supported by the Netherlands Organization for Scientific Research (NWO) , Vidi Grant number 13339 (N.P.), Vici Grant number 016.Vici.185.050 (S.O.D.), the National Institute of Mental Health of the National Institutes of Health under award number R01MH111417 (N.P.). A.F. is supported by a grant from the Biotechnology and Biology research council (BBSRC, grant number: BB/S006605/1 ) and the Bial Foundation , Bial Foundation Grants Programme 2020/21, A-29315 . Publisher Copyright: © 2021

PY - 2021/12

Y1 - 2021/12

N2 - Columns and layers are fundamental organizational units of the brain. Well known examples of cortical columns are the ocular dominance columns (ODCs) in primary visual cortex and the column-like stripe-based arrangement in the second visual area V2. The spatial scale of columns and layers is beyond the reach of conventional neuroimaging, but the advent of high field magnetic resonance imaging (MRI) scanners (UHF, 7 Tesla and above) has opened the possibility to acquire data at this spatial scale, in-vivo and non-invasively in humans. The most prominent non-invasive technique to measure brain function is blood oxygen level dependent (BOLD) fMRI, measuring brain activity indirectly, via changes in hemodynamics. A key determinant of the ability of high-resolution BOLD fMRI to accurately resolve columns and layers is the point-spread function (PSF) of the BOLD response in relation to the spatial extent of neuronal activity. In this study we take advantage of the stripe-based arrangement present in visual area V2, coupled with sub-millimetre anatomical and gradient-echo BOLD (GE BOLD) acquisition at 7 T to obtain PSF estimates and along cortical depth in human participants. Results show that the BOLD PSF is maximal in the superficial part of the cortex (1.78 mm), and it decreases with increasing cortical depth (0.83 mm close to white matter).

AB - Columns and layers are fundamental organizational units of the brain. Well known examples of cortical columns are the ocular dominance columns (ODCs) in primary visual cortex and the column-like stripe-based arrangement in the second visual area V2. The spatial scale of columns and layers is beyond the reach of conventional neuroimaging, but the advent of high field magnetic resonance imaging (MRI) scanners (UHF, 7 Tesla and above) has opened the possibility to acquire data at this spatial scale, in-vivo and non-invasively in humans. The most prominent non-invasive technique to measure brain function is blood oxygen level dependent (BOLD) fMRI, measuring brain activity indirectly, via changes in hemodynamics. A key determinant of the ability of high-resolution BOLD fMRI to accurately resolve columns and layers is the point-spread function (PSF) of the BOLD response in relation to the spatial extent of neuronal activity. In this study we take advantage of the stripe-based arrangement present in visual area V2, coupled with sub-millimetre anatomical and gradient-echo BOLD (GE BOLD) acquisition at 7 T to obtain PSF estimates and along cortical depth in human participants. Results show that the BOLD PSF is maximal in the superficial part of the cortex (1.78 mm), and it decreases with increasing cortical depth (0.83 mm close to white matter).

KW - 7Tesla

KW - BOLD

KW - Cortical depth

KW - Point-spread function

UR - https://www.scopus.com/pages/publications/85119411771

UR - https://www.scopus.com/inward/citedby.url?scp=85119411771&partnerID=8YFLogxK

U2 - 10.1016/j.pneurobio.2021.102187

DO - 10.1016/j.pneurobio.2021.102187

M3 - Article

AN - SCOPUS:85119411771

SN - 0301-0082

VL - 207

SP - 1

EP - 11

JO - Progress in Neurobiology

JF - Progress in Neurobiology

M1 - 102187

ER -

Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this