Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

R.A. Power, S. Steinberg, G. Bjornsdottir, C.A. Rietveld, A. Abdellaoui, M.G. Nivard, M. Johannesson, T.E. Galesloot, J.J. Hottenga, G. Willemsen, D. Cesarini, D.J. Benjamin, P.K. Magnusson, F. Ullén, H. Tiemeier, A. Hofman, F.J. van Rooij, G.B. Walters, E. Sigurdsson, T.E. ThorgeirssonA. Ingason, A. Helgason, A. Kong, L.A. Kiemeney, P.D. Koellinger, D.I. Boomsma, D. Gudbjartsson, H. Stefansson, K. Stefansson

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
Original languageEnglish
Pages (from-to)953-955
JournalNature Neuroscience
Volume18
Issue number7
DOIs
Publication statusPublished - 2015

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