Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

R.A. Power; S. Steinberg; G. Bjornsdottir; C.A. Rietveld; A. Abdellaoui; M.G. Nivard; M. Johannesson; T.E. Galesloot; J.J. Hottenga; G. Willemsen; D. Cesarini; D.J. Benjamin; P.K. Magnusson; F. Ullén; H. Tiemeier; A. Hofman; F.J. van Rooij; G.B. Walters; E. Sigurdsson; T.E. Thorgeirsson; A. Ingason; A. Helgason; A. Kong; L.A. Kiemeney; P.D. Koellinger; D.I. Boomsma; D. Gudbjartsson; H. Stefansson; K. Stefansson

doi:10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

R.A. Power, S. Steinberg, G. Bjornsdottir, C.A. Rietveld, A. Abdellaoui, M.G. Nivard, M. Johannesson, T.E. Galesloot, J.J. Hottenga, G. Willemsen, D. Cesarini, D.J. Benjamin, P.K. Magnusson, F. Ullén, H. Tiemeier, A. Hofman, F.J. van Rooij, G.B. Walters, E. Sigurdsson, T.E. ThorgeirssonA. Ingason, A. Helgason, A. Kong, L.A. Kiemeney, P.D. Koellinger, D.I. Boomsma, D. Gudbjartsson, H. Stefansson, K. Stefansson

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English
Pages (from-to)	953-955
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
Publication status	Published - 2015

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1038/nn.4040

Persistent URL (handle)

Persistent link

Cite this

Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. G., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K., Ullén, F., Tiemeier, H., Hofman, A., van Rooij, F. J., Walters, G. B., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

@article{c5941c517cc64e0fbb1667ea6bc24f5b,

title = "Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.",

abstract = "We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 {\^a} '6 and 3.8 × 10 {\^a} '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.",

author = "R.A. Power and S. Steinberg and G. Bjornsdottir and C.A. Rietveld and A. Abdellaoui and M.G. Nivard and M. Johannesson and T.E. Galesloot and J.J. Hottenga and G. Willemsen and D. Cesarini and D.J. Benjamin and P.K. Magnusson and F. Ull{\'e}n and H. Tiemeier and A. Hofman and {van Rooij}, F.J. and G.B. Walters and E. Sigurdsson and T.E. Thorgeirsson and A. Ingason and A. Helgason and A. Kong and L.A. Kiemeney and P.D. Koellinger and D.I. Boomsma and D. Gudbjartsson and H. Stefansson and K. Stefansson",

year = "2015",

doi = "10.1038/nn.4040",

language = "English",

volume = "18",

pages = "953--955",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "7",

}

Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, CA, Abdellaoui, A, Nivard, MG, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PK, Ullén, F, Tiemeier, H, Hofman, A, van Rooij, FJ, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, PD , Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.', Nature Neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

TY - JOUR

T1 - Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

AU - Power, R.A.

AU - Steinberg, S.

AU - Bjornsdottir, G.

AU - Rietveld, C.A.

AU - Abdellaoui, A.

AU - Nivard, M.G.

AU - Johannesson, M.

AU - Galesloot, T.E.

AU - Hottenga, J.J.

AU - Willemsen, G.

AU - Cesarini, D.

AU - Benjamin, D.J.

AU - Magnusson, P.K.

AU - Ullén, F.

AU - Tiemeier, H.

AU - Hofman, A.

AU - van Rooij, F.J.

AU - Walters, G.B.

AU - Sigurdsson, E.

AU - Thorgeirsson, T.E.

AU - Ingason, A.

AU - Helgason, A.

AU - Kong, A.

AU - Kiemeney, L.A.

AU - Koellinger, P.D.

AU - Boomsma, D.I.

AU - Gudbjartsson, D.

AU - Stefansson, H.

AU - Stefansson, K.

PY - 2015

Y1 - 2015

N2 - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

AB - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

U2 - 10.1038/nn.4040

DO - 10.1038/nn.4040

M3 - Article

SN - 1097-6256

VL - 18

SP - 953

EP - 955

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Abstract

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this