Abstract
Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF-maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake non-human primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF-models based on the fMRI BOLD-signal, multi-unit spiking activity (MUA) and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. FMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF-size with increasing eccentricity, as well as a retinotopically specific deactivation of default-mode network nodes similar to previous observations in humans.
| Original language | English |
|---|---|
| Article number | e67304 |
| Pages (from-to) | 1-35 |
| Number of pages | 35 |
| Journal | eLife |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 3 Nov 2021 |
Bibliographical note
Funding Information:785907, “Human Brain Project SGA1 and SGA2”), and the Friends Foundation of the Netherlands Institute
Funding Information:
This work was supported by NWO (Crossover Program 17619 ?INTENSE?; STW-Perspectief P15-42 ?NESTOR?; VENI 451.13.023), the European Union FP7 (ERC 339490 ?Cortic_al_gorithms?), the Human Brain Project (agreements 720270 and 785907, ?Human Brain Project SGA1 and SGA2?), and the Friends Foundation of the Netherlands Institute for Neuroscience.
Funding Information:
We thank Jonathan Williford for his contributions to the fMRI preprocessing pipeline; Pieter Buur, Wietske van der Zwaag, Diederick Stoffers, and the Laboratory of Neuro-and Psychophysiology of KU Leuven for technical assistance in setting up the non-human primate MR infrastructure; Kor Brandsma, Anneke Ditewig, and Lex Beekman for animal care and biotechnical assistance; Feng Wang for help with electrophysiology data collection; Chris van der Togt for help with data management; and Tomas Knapen and Serge Dumoulin for fruitful discussion and comments on an earlier version of the manuscript. This work was supported by NWO (Crossover Program 17619 “INTENSE”; STW-Perspectief P15-42 “NESTOR”; VENI 451.13.023), the European Union FP7 (ERC 339490 “Cortic_al_gorithms”), the Human Brain Project (agreements 720270 and
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