Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

Andries T. Marees; Dirk J.A. Smit; Jue Sheng Ong; Stuart Macgregor; Jiyuan An; Damiaan Denys; Florence Vorspan; Wim Van Den Brink; Eske M. Derks

doi:10.1017/S0033291719000357

Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

Andries T. Marees^*, Dirk J.A. Smit, Jue Sheng Ong, Stuart Macgregor, Jiyuan An, Damiaan Denys, Florence Vorspan, Wim Van Den Brink, Eske M. Derks

^*Corresponding author for this work

Economics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (r _g ) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (r _g = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.

Original language	English
Pages (from-to)	484-498
Number of pages	15
Journal	Psychological Medicine
Volume	50
Issue number	3
Early online date	1 Jan 2019
DOIs	https://doi.org/10.1017/S0033291719000357
Publication status	Published - Feb 2020

Keywords

Alcohol consumption
genetic correlation
genetics
socioeconomic status
substance use

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10.1017/S0033291719000357

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@article{ae1e41c166994eafb964fdfe41c19ac4,

title = "Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health",

abstract = " Background. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (r g ) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (r g = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes. ",

keywords = "Alcohol consumption, genetic correlation, genetics, socioeconomic status, substance use",

author = "Marees, {Andries T.} and Smit, {Dirk J.A.} and Ong, {Jue Sheng} and Stuart Macgregor and Jiyuan An and Damiaan Denys and Florence Vorspan and {Van Den Brink}, Wim and Derks, {Eske M.}",

year = "2020",

month = feb,

doi = "10.1017/S0033291719000357",

language = "English",

volume = "50",

pages = "484--498",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "3",

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Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health. / Marees, Andries T.; Smit, Dirk J.A.; Ong, Jue Sheng; Macgregor, Stuart; An, Jiyuan; Denys, Damiaan; Vorspan, Florence; Van Den Brink, Wim; Derks, Eske M.

In: Psychological Medicine, Vol. 50, No. 3, 02.2020, p. 484-498.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

AU - Marees, Andries T.

AU - Smit, Dirk J.A.

AU - Ong, Jue Sheng

AU - Macgregor, Stuart

AU - An, Jiyuan

AU - Denys, Damiaan

AU - Vorspan, Florence

AU - Van Den Brink, Wim

AU - Derks, Eske M.

PY - 2020/2

Y1 - 2020/2

N2 - Background. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (r g ) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (r g = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.

AB - Background. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (r g ) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (r g = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.

KW - Alcohol consumption

KW - genetic correlation

KW - genetics

KW - socioeconomic status

KW - substance use

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DO - 10.1017/S0033291719000357

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EP - 498

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 3

ER -

Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

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