In 2006 we published an article on 50 determinants of innovations in health care organizations. A brief description of all determinants and their influence was given. Implementation researchers and implementation consultants or advisors have asked us repeatedly to publish a full description of the determinants. The full description of the determinants and an indication of the influence of both extremes of a determinant (e.g. low vs high staff turnover) on the innovation process are given in this article.