Pravastatin and cognitive function in the elderly. Results of the PROSPER study

S. Trompet, P. van Vliet, A.J. de Craen, J. Jolles, B.M. Buckley, E.H. Gronenschild, M.B. Murphy, I. Ford, P.W. Macfarlane, N. Sattar, C.J. Packard, D.J. Stott, J. Shepherd, E.L. Bollen, G.J. Blauw, J.W. Jukema, R.G. Westendorp

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile. © 2009 Springer-Verlag.
Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalJournal of Neurology
Volume257
Issue number1
DOIs
Publication statusPublished - 2009

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Pravastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cognition
Prospective Studies
Observational Studies
Placebos
Neuropsychological Tests
Prescriptions
Dementia
Randomized Controlled Trials
Cognitive Dysfunction
Therapeutics

Cite this

Trompet, S., van Vliet, P., de Craen, A. J., Jolles, J., Buckley, B. M., Gronenschild, E. H., ... Westendorp, R. G. (2009). Pravastatin and cognitive function in the elderly. Results of the PROSPER study. Journal of Neurology, 257(1), 85-90. https://doi.org/10.1007/s00415-009-5271-7
Trompet, S. ; van Vliet, P. ; de Craen, A.J. ; Jolles, J. ; Buckley, B.M. ; Gronenschild, E.H. ; Murphy, M.B. ; Ford, I. ; Macfarlane, P.W. ; Sattar, N. ; Packard, C.J. ; Stott, D.J. ; Shepherd, J. ; Bollen, E.L. ; Blauw, G.J. ; Jukema, J.W. ; Westendorp, R.G. / Pravastatin and cognitive function in the elderly. Results of the PROSPER study. In: Journal of Neurology. 2009 ; Vol. 257, No. 1. pp. 85-90.
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abstract = "Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile. {\circledC} 2009 Springer-Verlag.",
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Trompet, S, van Vliet, P, de Craen, AJ, Jolles, J, Buckley, BM, Gronenschild, EH, Murphy, MB, Ford, I, Macfarlane, PW, Sattar, N, Packard, CJ, Stott, DJ, Shepherd, J, Bollen, EL, Blauw, GJ, Jukema, JW & Westendorp, RG 2009, 'Pravastatin and cognitive function in the elderly. Results of the PROSPER study' Journal of Neurology, vol. 257, no. 1, pp. 85-90. https://doi.org/10.1007/s00415-009-5271-7

Pravastatin and cognitive function in the elderly. Results of the PROSPER study. / Trompet, S.; van Vliet, P.; de Craen, A.J.; Jolles, J.; Buckley, B.M.; Gronenschild, E.H.; Murphy, M.B.; Ford, I.; Macfarlane, P.W.; Sattar, N.; Packard, C.J.; Stott, D.J.; Shepherd, J.; Bollen, E.L.; Blauw, G.J.; Jukema, J.W.; Westendorp, R.G.

In: Journal of Neurology, Vol. 257, No. 1, 2009, p. 85-90.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Pravastatin and cognitive function in the elderly. Results of the PROSPER study

AU - Trompet, S.

AU - van Vliet, P.

AU - de Craen, A.J.

AU - Jolles, J.

AU - Buckley, B.M.

AU - Gronenschild, E.H.

AU - Murphy, M.B.

AU - Ford, I.

AU - Macfarlane, P.W.

AU - Sattar, N.

AU - Packard, C.J.

AU - Stott, D.J.

AU - Shepherd, J.

AU - Bollen, E.L.

AU - Blauw, G.J.

AU - Jukema, J.W.

AU - Westendorp, R.G.

PY - 2009

Y1 - 2009

N2 - Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile. © 2009 Springer-Verlag.

AB - Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cognitive function was assessed repeatedly in all 5,804 PROSPER participants at six different time points during the study using four neuropsychological performance tests. After a mean follow-up period of 42 months, no difference in cognitive decline at any of the cognitive domains was found in subjects treated with pravastatin compared to placebo (all p > 0.05). Pravastatin treatment in old age did not affect cognitive decline during a 3 year follow-up period. Employing statin therapy in the elderly in an attempt to prevent cognitive decline therefore seems to be futile. © 2009 Springer-Verlag.

U2 - 10.1007/s00415-009-5271-7

DO - 10.1007/s00415-009-5271-7

M3 - Article

VL - 257

SP - 85

EP - 90

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 1

ER -